Early Detection and Screening for Colorectal Neoplasia: Making Sense of the Guidelines
- Robert S. Bresalier
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Each year, approximately 1 million new cases of colorectal cancer (CRC) occur worldwide, with substantial morbidity and mortality. For colon cancer in the United States, 147,000 new cases and 50,000 colon cancer-related deaths have been estimated for the coming year. The long natural history of colorectal neoplasia affords the opportunity to improve survival from this disease through preventive measures. Currently, screening for adenomatous polyps and early-stage cancers provides the best opportunity to improve survival. Growing knowledge of CRC pathogenesis and its natural history is allowing the development of new tools to identify those who will benefit most from colon cancer screening and is defining proper surveillance intervals. Recently, guidelines for screening for colorectal neoplasia were revised substantially by several organizations, based on developing technologies and a growing body of data regarding the efficacy of CRC screening.
Guidelines: Understanding the Updates
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- US Preventive Services Task Force: Screening for colorectal cancer: US Preventive Services Task Force recommendation statement. Ann Intern Med 2008; 149:627–637.
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- Atkin W, Edwards R, Kralj-Hans I, et al.: Once-only flexible sigmoidoscopy screening in the prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet 2010; 375:1624–1633. CrossRef
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- Early Detection and Screening for Colorectal Neoplasia: Making Sense of the Guidelines
Current Colorectal Cancer Reports
Volume 6, Issue 4 , pp 177-179
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- Current Science Inc.
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- Author Affiliations
- 1. Department of Gastroenterology, Hepatology and Nutrition, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1466, Houston, TX, 77030, USA