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Cystectomy for Neurogenic Bladder

  • Neurogenic Bladder (C Powell, Section Editor)
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Abstract

Patients with a myriad of neurologic conditions can develop urinary symptoms as a result of impaired bladder function. Conservative management options for neurogenic bladder (NGB) may include catheterization and medical therapy. However, refractory individuals may require more aggressive intervention such as onabotulinumtoxinA injections or bladder augmentation. As a last resort, urinary diversion may be indicated for end-stage lower urinary tract dysfunction secondary to NGB. Urinary diversion may be performed with or without cystectomy. However, leaving the defunctionalized bladder in situ may lead to pyocystis, secondary carcinoma, or pain. As a result, there has been an increasing trend to perform a concomitant cystectomy at the time of urinary diversion. While this eliminates the sequelae of the retained bladder, performing a cystectomy at the time of urinary diversion can also increase the morbidity of the procedure.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Brown ET, Krlin R, Winters JC. Urodynamics: examining the current role of UDS testing. What is the role of urodynamic testing in light of recent AUA Urodynamics and Overactive Bladder Guidelines and the VALUE study? Lower Urinary Tract Symptoms and Voiding Dysfunction. Curr Urol Rep. 2013;14(5):403–8.

    Article  PubMed  Google Scholar 

  2. Winters JC, Dmochowski RR, Goldman HB, et al. Urodynamic studies in adults: AUA/SUFU guideline. J Urol. 2012;188:2464–72. Summary of the AUA Guidelines on Urodynamics.

  3. Ginsberg D. Indications and complications of cystectomy in patients with neurogenic bladder. J Urol. 2010;184:10–1.

    Article  PubMed  Google Scholar 

  4. Kurpad R, Kennelly M. The evaluation and management of refractory neurogenic overactive bladder. Curr Urol Rep. 2014;15:444.

    Article  PubMed  Google Scholar 

  5. Goessaert A, Everaert K. Onabotulinum toxin A for the treatment of neurogenic detrusor overactivity due to spinal cord injury or multiple sclerosis. Expert Rev Neurother. 2012;12(7):763–75.

    Article  CAS  PubMed  Google Scholar 

  6. Lisenmeyer TA. Use of botulinum toxin in individuals with neurogenic detrusor overactivity: state of the art review. J Spinal Cord Med. 2013;36(5):402–19.

    Article  Google Scholar 

  7. Sajadi KP, Goldman HB. Bladder augmentation and urinary diversion for neurogenic LUTS: current indications. Curr Urol Rep. 2012;13:389–93.

    Article  PubMed  Google Scholar 

  8. Gamé X, Castel-Lacanal E, Bentaleb Y, et al. Botulinum toxin detrusor injections in patients with neurogenic detrusor overactivity significantly decrease the incidence of urinary tract infections. Eur Urol. 2008;53(3):613–8.

    Article  PubMed  Google Scholar 

  9. Gurung, Attar KH, Abdul-Rahman A, et al. Long-term outcomes of augmentation ileocystoplasty in patients with spinal cord injury: a minimum of 10 years of follow-up. BJU Int. 2012;109:1236–42.

    Article  PubMed  Google Scholar 

  10. Rowley M, Clemens J, Latini J, et al. Simple cystectomy: outcomes of a new operative technique. Urology. 2011;78:942–5. Describes the supratrigonal technique for cystectomy that we currently employ.

    Article  PubMed  Google Scholar 

  11. Singh G, Wilkinson JM, Thomas DG. Supravesical diversion for incontinence: a long-term follow-up. Br J Urol. 1998;79:348–53.

    Article  Google Scholar 

  12. Chartier-Kastler EJ, Mozer P, Denys P, et al. Neurogenic bladder management and cutaneous non-continent ileal conduit. Spinal Cord. 2002;40:443–8.

    Article  CAS  PubMed  Google Scholar 

  13. Eigner EB, Freiha FS. The fate of the remaining bladder following supravesical diversion. J Urol. 1990;144:31.

    CAS  PubMed  Google Scholar 

  14. Lawrence A, Hu B, Lee O, et al. Pyocystis after urinary diversion for incontinence—is a concomitant cystectomy necessary? Urology. 2013;82(5):1161–5.

    Article  PubMed  Google Scholar 

  15. Cheng JN, Lawrentschuk N, Gyomber D, et al. Cystectomy in patients with spinal cord injury: indications and long-term outcomes. J Urol. 2010;184(1):92–8.

    Article  PubMed  Google Scholar 

  16. Groah SL, Weitzenkamp DA, Lemmertse DP, et al. Excess risk of bladder cancer in spinal cord injury: evidence for an association between indwelling catheter use and bladder cancer. Arch Phys Med Rehabil. 2002;83:346.

    Article  PubMed  Google Scholar 

  17. Cohn J, Large M, Richards K, et al. Cystectomy and urinary diversion as management of treatment-refractory benign disease: the impact of preoperative urological conditions on perioperative outcomes. Int J Urol. 2014;21:382–6.

    Article  PubMed  Google Scholar 

  18. Chong J, Dolat MT, Klausner A, et al. The role of cystectomy for non-malignant bladder conditions: a review. Can J Urol. 2014;21(5):7433–41.

    PubMed  Google Scholar 

  19. Neulander E, Rivera I, Eisenbrown N, et al. Simple cystectomy in patients requiring urinary diversion. J Urol. 2000;164:1169–72.

    Article  CAS  PubMed  Google Scholar 

  20. Gobeaux N, Yates D, Denys P, et al. Supratrigonal cystectomy with Hautmann pouch as treatment for neurogenic bladder in spinal cord injury patients: long-term functional results. Neurourol Urodyn. 2012;31:672–6.

    Article  PubMed  Google Scholar 

  21. Osborn D, Dmochowski R, Kaufman M, et al. Cystectomy with urinary diversion for benign disease: indications and outcomes. Urology. 2014;84:1433–7.

    Article  Google Scholar 

  22. Legrand G, Rouprêt M, Comperat E, et al. Functional outcomes after management of end-stage neurological bladder dysfunction with ileal conduit in a multiple sclerosis population: a monocentric experience. Urology. 2011;78(4):937–41.

    Article  PubMed  Google Scholar 

  23. Guillotreau J, Castel-Lacanal, Roumiguié M, et al. Prospective study of the impact on quality of life of cystectomy with ileal conduit urinary diversion for neurogenic bladder dysfunction. Neurourol Urodyn. 2011;30:1503–6.

    Article  PubMed  Google Scholar 

  24. Moore D, Cohn J, Brown ET, et. al. Post-operative complications after laparotomy in adult patients with spina bifida. Presented at the 2016 Society of Urodynamics, Female Pelvic Medicine, and Urogenital Reconstruction conference in New Orleans, LA.

  25. Brown ET, Osborn D, Mock S, et. al. Perioperative complications of conduit urinary diversion with concomitant cystectomy for benign indications: a population-based analysis. Neurourol Urodyn. 2016. doi:10.1002/nau.23135. National analysis of complications of cystectomy for bengin indications.

  26. Brown ET, Osborn D, Mock S, et. al. Temporal trends in conduit urinary diversion with concomitant cystectomy for benign indications: a population-based analysis. Urology. 2016. doi:10.1016/j.urology.2016.06.035National analysis of outcomes for cystectomy for benign indications.

  27. Cody JD, Nabi G, Dublin N, et al. Urinary diversion and bladder reconstruction/replacement using intestinal segments for intractable incontinence or following cystectomy. Cochrane Database Syst Rev 2012;2.

  28. Stohrer M, Blok B, Castro-Diaz D, et al. EAU guidelines on neurogenic lower urinary tract dysfunction. Eur Urol. 2009;56:81–8.

    Article  PubMed  Google Scholar 

  29. Klausner AP, Steers WD. The neurogenic bladder: an update with management strategies for primary care physicians. Med Clin N Am. 2011;95(1):111–20.

    Article  PubMed  Google Scholar 

  30. Chen G, Liao L. Sacral neuromodulation for neurogenic bladder and bowel dysfunction with multiple symptoms secondary to spinal cord disease. Spinal Cord. 2014.

  31. Lombardi G, Musco S, Celso M, Del Corso F, Del Popolo G. Sacral neuromodulation for neurogenic non-obstructive urinary retention in incomplete spinal cord patients: a ten-year follow-up single-centre experience. Spinal Cord. 2014;52(3):241–5.

    Article  CAS  PubMed  Google Scholar 

  32. Wöllner J, Krebs J, Pannek J. Sacral neuromodulation in patients with neurogenic lower urinary tract dysfunction. Spinal Cord. 2016;54(2):137–40.

    Article  PubMed  Google Scholar 

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Correspondence to Elizabeth Timbrook Brown.

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Conflict of Interest

Drs Brown, Cohn, Kaufman, Milam, Dmochowski, and Reynolds declare no relevant conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain studies with human or animal subjects performed by the author.

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This article is part of the Topical Collection on Neurogenic Bladder

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Brown, E.T., Cohn, J.A., Kaufman, M.R. et al. Cystectomy for Neurogenic Bladder. Curr Bladder Dysfunct Rep 11, 341–345 (2016). https://doi.org/10.1007/s11884-016-0389-9

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  • DOI: https://doi.org/10.1007/s11884-016-0389-9

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