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Role of ion channels in bladder function and voiding disorders

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Abstract

Ion channels are diverse, ubiquitous membrane proteins in both excitable and nonexcitable cells. Calcium, potassium, sodium, and chloride channels mediate flow of ions across smooth muscle (detrusor, urethra), neural membranes (afferent and efferent axons, terminals, and ganglion cells), and sometimes urothelium. These channels all respond to physiologic stimuli by opening pores gated by ions, changes in membrane potential, G proteins (ligands), and mechanical stimuli. There is substantial interest in the role of ion channels in spontaneous detrusor or afferent activity because new agents to treat overactive bladder and bladder pain syndromes are needed. Repeated injury, mechanical stimuli, and inflammatory cytokines may alter these channels, leading to common voiding disorders and pain. Some individuals may even express isoforms or splice variants of ion channels that predispose them to overactive bladder or pain. This brief overview highlights recent findings relating to ion channels and their potential role in micturition.

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Authors and Affiliations

  1. Department of Urology, University of Virginia School of Medicine, Box 800422, Hospital Drive, Charlottesville, VA, 22908, USA

    William D. Steers

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  1. William D. Steers
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  2. Jeremy B. Tuttle
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Correspondence to William D. Steers.

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Steers, W.D., Tuttle, J.B. Role of ion channels in bladder function and voiding disorders. Curr Bladder Dysfunct Rep 4, 125–131 (2009). https://doi.org/10.1007/s11884-009-0018-y

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