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Antiplatelet therapy in secondary stroke prevention

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Abstract

This article focuses on recent data about the safety and effectiveness of antiplatelet therapies for secondary stroke prevention. Highlights include a discussion of changes in the professional labeling for aspirin and the results of a low- versus high-dose aspirin trial (Aspirin after Carotid Endarterectomy trial). Safety issues regarding aspirin also are considered. Other topics include a review of recent data on thrombotic thrombocytopenic purpura (TTP) associated with ticlopidine and a brief update on clopidogrel. A summary of discussions related to the European Stroke Prevention Study 2 data and Food and Drug Administration consideration of combination dipyridamole/aspirin therapy are presented.

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Authors and Affiliations

  1. Department of Neurology, University of Virginia Health Systems #394, 22908, Charlottesville, VA, USA

    Bradford B. Worrall MD & Karen C. Johnston MD

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  1. Bradford B. Worrall MD
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  2. Karen C. Johnston MD
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Worrall, B.B., Johnston, K.C. Antiplatelet therapy in secondary stroke prevention. Curr Atheroscler Rep 2, 104–109 (2000). https://doi.org/10.1007/s11883-000-0103-3

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