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The Nasal and Sinus Microbiome in Health and Disease

  • RHINOSINUSITIS (J MULLOL, SECTION EDITOR)
  • Published:
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Abstract

There has been great interest in unraveling the complex inter-relationships between microbes and humans as they relate to human health and disease. This review will focus on recent advances in the appreciation and understanding of these relationships in terms of the upper respiratory tract, specifically the nose and paranasal sinuses.

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Abbreviations

CNS:

Coagulase-negative Staphylococcus

CRS:

Chronic rhinosinusitis

CSLM:

Confocal scanning laser microscopy

FISH:

Fluorescence in situ hybridization

HC:

Healthy control(s)

hBD:

Human beta defensin

IESA:

Intraepithelial Staphyloccus aureus

MRSA:

Methicillin-resistant Staphylococcus aureus

NO:

Nitric oxide

OTU:

Operational taxonomic unit

SEM:

Scanning electron microscopy

T2R38:

A bitter taste receptor

TAS2R38:

A bitter taste receptor polymorphism

TEM:

Transmission electron microscopy

TLR:

Toll-like receptor

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Conflict of Interest

Michael T. Wilson and Daniel L. Hamilos report no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by the authors.

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Authors and Affiliations

  1. The Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, 55 Fruit Street, Cox 2-201, Boston, MA, 02114, USA

    Michael T. Wilson

  2. The Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Bulfinch-422, Boston, MA, 02114, USA

    Daniel L. Hamilos

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  1. Michael T. Wilson
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Correspondence to Daniel L. Hamilos.

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This article is part of the Topical Collection on Rhinosinusitis

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Wilson, M.T., Hamilos, D.L. The Nasal and Sinus Microbiome in Health and Disease. Curr Allergy Asthma Rep 14, 485 (2014). https://doi.org/10.1007/s11882-014-0485-x

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