Current Allergy and Asthma Reports

, Volume 13, Issue 4, pp 347-353

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Celiac Disease and Autoimmunity: Review and Controversies

  • Jolanda M. DenhamAffiliated withNationwide Children’s Hospital, The Ohio State University School of Medicine Email author 
  • , Ivor D. HillAffiliated withNationwide Children’s Hospital, The Ohio State University School of Medicine


Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. There is a strong linkage between CD and HLA-DQ2 and HLA-DQ8 haplotypes. Multiple case reports and small series suggest concordance between CD and other autoimmune disorders. This paper provides a brief overview of the pathogenesis of CD and reviews the literature regarding associations between CD and other autoimmune diseases, including the potential effects of gluten-free diet therapy on the prevention or amelioration of associated diseases.


Celiac Celiac disease Autoimmune Addison’s disease Addison’s Type 1 diabetes Autoimmune thyroiditis Hashimoto’s thyroiditis Graves disease Cryptogenic hepatitis Celiac hepatitis Primary biliary cirrhosis Sjogren’s syndrome Systemic lupus erythematous SLE Lupus Antiphospholipid syndrome Psoriasis Vitiligo Alopecia acreta Dermatitis herpetiformis