ANAPHYLAXIS AND DRUG ALLERGY (P LIEBERMAN AND S SPECTOR, SECTION EDITORS)

Current Allergy and Asthma Reports

, Volume 13, Issue 1, pp 58-63

Allergen Component Testing for Food Allergy: Ready for Prime Time?

  • Jacob D. KattanAffiliated withDivision of Pediatric Allergy & Immunology and Jaffe Institute for Food Allergy, The Mount Sinai School of MedicineDepartment of Pediatrics, Box 1198, The Mount Sinai School of Medicine Email author 
  • , Julie WangAffiliated withDivision of Pediatric Allergy & Immunology and Jaffe Institute for Food Allergy, The Mount Sinai School of MedicineDepartment of Pediatrics, Box 1198, The Mount Sinai School of Medicine

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Abstract

Food allergies can cause life-threatening reactions and greatly influence quality of life. Accurate diagnosis of food allergies is important to avoid serious allergic reactions and prevent unnecessary dietary restrictions, but can be difficult. Skin prick testing (SPT) and serum food-specific IgE (sIgE) levels are extremely sensitive testing options, but positive test results to tolerated foods are not uncommon. Allergen component-resolved diagnostics (CRD) have the potential to provide a more accurate assessment in diagnosing food allergies. Recently, a number of studies have demonstrated that CRD may improve the specificity of allergy testing to a variety of foods including peanut, milk, and egg. While it may be a helpful adjunct to current diagnostic testing, CRD is not ready to replace existing methods of allergy testing, as it not as sensitive, is not widely available, and evaluations of component testing for a number of major food allergens are lacking.

Keywords

Food allergy Diagnosis Skin prick testing Food-specific IgE Sensitivity Specificity Oral food challenge Component-resolved diagnostics Microarray Milk allergy Hazelnut allergy Egg allergy Peanut allergy Shrimp allergy