Exercise-Induced Anaphylaxis: An Update on Diagnosis and Treatment
Exercise-induced anaphylaxis (EIA) and food-dependent, exercise-induced anaphylaxis (FDEIA) are rare but potentially life-threatening clinical syndromes in which association with exercise is crucial. The range of triggering physical activities is broad, including as mild an effort as a stroll. EIA is not fully repeatable (ie, the same exercise may not always result in anaphylaxis in a given patient). In FDEIA, the combined ingestion of sensitizing food and exercise is necessary to precipitate symptoms. Clinical features and management do not differ significantly from other types of anaphylaxis. The pathophysiology of EIA and FDEIA is not fully understood. Different hypotheses concerning the possible influence of exercise on the development of anaphylactic symptoms are taken into consideration. These include increased gastrointestinal permeability, blood flow redistribution, and most likely increased osmolality. This article also describes current diagnostic and therapeutic possibilities, including changes in lifestyle and preventive properties of antiallergic drugs as well as acute treatment of these dangerous syndromes.
- Exercise-Induced Anaphylaxis: An Update on Diagnosis and Treatment
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Current Allergy and Asthma Reports
Volume 11, Issue 1 , pp 45-51
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
- Additional Links
- Exercise-induced anaphylaxis
- Food-dependent, exercise-induced anaphylaxis
- Mast cell
- Food allergy
- Industry Sectors
- Author Affiliations
- 1. Department of Physiology, Medical University of Wroclaw, Wroclaw, Poland
- 2. Department of Internal Diseases, Geriatrics, and Allergology, Medical University of Wroclaw, 57 Traugutta Street, 50-417, Wroclaw, Poland
- 3. Department of Clinical Research, Medical School of Legnica, Legnica, Poland