Current Allergy and Asthma Reports

, Volume 9, Issue 4, pp 265–272

Abnormal skin barrier in the etiopathogenesis of atopic dermatitis

Authors

    • Dermatology Service (190)VA Medical Center
  • Matthias Schmuth
Article

DOI: 10.1007/s11882-009-0037-y

Cite this article as:
Elias, P.M. & Schmuth, M. Curr Allergy Asthma Rep (2009) 9: 265. doi:10.1007/s11882-009-0037-y

Abstract

Prior studies revealed the key roles played by T-helper type 1 and type 2 (Th1/Th2) cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the evolution of the chronic, pruritic, inflammatory dermatosis that characterizes atopic dermatitis (AD). Accordingly, current therapy has been largely directed toward ameliorating Th2-mediated inflammation and pruritus. This article reviews emerging evidence that the inflammation in AD results from inherited and acquired insults to the barrier, as well as the therapeutic implications of this new paradigm.

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© Current Medicine Group, LLC 2009