Current Allergy and Asthma Reports

, Volume 8, Issue 4, pp 312–317

Stress and atopic dermatitis

Authors

  • Jenna Arndt
  • Nananamibia Smith
    • Department of DermatologyUniversity of Rochester School of Medicine and Dentistry
Article

DOI: 10.1007/s11882-008-0050-6

Cite this article as:
Arndt, J., Smith, N. & Tausk, F. Curr Allergy Asthma Rep (2008) 8: 312. doi:10.1007/s11882-008-0050-6

Abstract

Atopic dermatitis (AD) is a complex disease traditionally involving interaction of genetic, environmental, and immunologic factors. Recent studies suggest psychoneuro-immunologic factors and emotional stress are important in its evolution. The observations that internal (bacterial infections) or external (psychologic) stressors may induce AD flares is explained by studies showing that stress impairs the skin barrier function and favors a shift in immunity toward a T helper type 2 cell/allergic response. Furthermore, those with AD appear to have an inherited hypothalamic deficiency that impairs normal hypothalamic-pituitary-adrenal axis function. Neuropeptides released in the skin may also mediate neurogenic inflammation, including mast cell degranulation. AD causes significant stress and impaired quality of life in patients and their family members. Psychologic and stress-reduction interventions were recently shown to improve patient well-being, and to significantly improve cutaneous manifestations.

Copyright information

© Springer Science+Business Media, LLC 2008