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The role of regulatory t lymphocytes in asthma pathogenesis

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Abstract

Several subtypes of regulatory or suppressive T cells have been described that can prevent activation of effector T cells in vitro and in vivo in animal models. Recent evidence suggests a deficit in suppressive activity of both CD4+CD25+ regulatory T cells, and interleukin (IL)•10 producing regulatory T cells may play a role in development of allergic sensitization. If therapies can be devised to redress the balance between regulatory and effector T cells, there may be hope for the control and prevention of asthma.

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  1. Leukocyte Biology Section, Biomedical Sciences Division and Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, SW7 2AZ, London, England

    Douglas S. Robinson MD, FRCP

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Robinson, D.S. The role of regulatory t lymphocytes in asthma pathogenesis. Curr Allergy Asthma Rep 5, 136–141 (2005). https://doi.org/10.1007/s11882-005-0087-8

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