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The duration of gonadotropin stimulation does not alter the clinical pregnancy rate in IVF or ICSI cycles

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Abstract

Background

Ovarian stimulation is an essential part of assisted reproduction treatments. Research on whether the duration of stimulation alters the success in assisted reproduction has not been conclusive.

Aim

The purpose of the study was to establish whether the duration of ovarian stimulation alters the success in assisted reproduction treatments.

Methods

All fresh (non-donor) stimulation cycles performed in an academic tertiary referral ART centre over a period of 18 years, between 1st January 1997 and 31st December 2014, were identified. Data were prospectively and electronically collected. IVF and ICSI cycles were analysed independently. Each category was then subdivided into assisted reproduction cycles where the antagonist, long (down regulation) and flare protocol were used. Clinical pregnancy was the main outcome measured. A total of 10,478 stimulation cycles (6011 fresh IVF and 4467 fresh ICSI) reaching egg collection were included.

Results

We showed no significant difference in CP rates in IVF cycles for the long (p = 0.082), antagonist (p = 0.217) or flare (p = 0.741) protocol cycles or in ICSI cycles with the long (p = 0.223), antagonist (p = 0.766) or the flare (p = 0.690) protocol with regards the duration of stimulation.

Conclusion

The duration of stimulation does not alter the CP rate in ICSI or IVF cycles using the long, antagonist or flare stimulation protocol.

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References

  1. Ryan A, Wang S, Alvero R et al (2014) Prolonged gonadotropin stimulation for assisted reproductive technology cycles is associated with decreased pregnancy rates for all women except for women with polycystic ovary syndrome. J Assist Reprod Genet 31(7):837–842

    Article  PubMed  PubMed Central  Google Scholar 

  2. Bonilla-Musoles F, Castillo JC, Caballero O et al (2012) Predicting ovarian reserve and reproductive outcome using antimüllerian hormone (AMH) and antral follicle count (AFC) in patients with previous assisted reproduction technique (ART) failure. Clin Exp Obstet Gynecol 39(1):13–18

    CAS  PubMed  Google Scholar 

  3. Martin JS, Nisker JA, Tummon IS et al (1996) Future in vitro fertilization pregnancy potential of women with variably elevated day 3 follicle-stimulating hormone levels. Fertil Steril 65:1238–1240

    Article  CAS  PubMed  Google Scholar 

  4. Hock DL, Louie H, Shelden RM et al (1998) The need to step up the gonadotropin dosage in the stimulation phase of IVF treatment predicts a poor outcome. J Assist Reprod Genet 15:427–430

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Maheshwari A, Stofberg L, Bhattacharya S (2007) Effect of overweight and obesity on assisted reproductive technology—a systematic review. Hum Reprod Update. 13:433–444

    Article  CAS  PubMed  Google Scholar 

  6. Baker VL, Luke B, Brown MB et al (2010) Multivariate analysis of factors affecting probability of pregnancy and live birth with in vitro fertilization: an analysis of the society for assisted reproductive technology clinic outcomes reporting system. Fertil Steril 94:1410–1416

    Article  PubMed  Google Scholar 

  7. Huang JYJ, Rosenwaks Z (2012) In vitro fertilisation treatment and factors affecting success. Best Pract Res Clin Obstet Gynaecol 26:777–788

    Article  PubMed  Google Scholar 

  8. Chuang M, Zapantis A, Taylor M et al (2010) Prolonged gonadotropin stimulation is associated with decreased ART success. J Assist Reprod Genet 27:711–717. doi:10.1007/s10815-010-9476-6

    Article  PubMed  PubMed Central  Google Scholar 

  9. Martin JR, Mahutte NG, Arici A et al (2006) Impact of duration and dose of gonadotrophins on IVF outcomes. Reprod Biomed Online. 13:645–650

    Article  CAS  PubMed  Google Scholar 

  10. Chen SL, Sun L, Kong LH, Li L et al (2007) Clinical outcome of patients with follicular development retardation by prolonged duration of gonadotropin administration for in vitro fertilization. Zhonghua Fu Chan Ke Za Zhi. 42:526–529

    CAS  PubMed  Google Scholar 

  11. Youssef MA, Abdelmoty HI, Ahmed MA et al (2015) GnRH agonist for final oocyte maturation in GnRH antagonist co-treated IVF/ICSI treatment cycles: systematic review and meta-analysis. J Adv Res. 6(3):341–349

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Samara N, Reis D, Danielli Miller N et al (2015) What are the best predictors for successful GnRH antagonist protocol in vitro fertilization (IVF) treatment? Gynecol Endocrinol 29:1–3

    Google Scholar 

  13. Mardešič T, Mannaerts B, Abuzeid M et al (2014) Short follicular phase of stimulation following corifollitropin alfa or daily recombinant FSH treatment does not compromise clinical outcome: a retrospective analysis of the Engage trial. Reprod Biomed Online. 28(4):462–468

    Article  PubMed  Google Scholar 

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Acknowledgements

No funding was required for this project.

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Authors and Affiliations

  1. Rotunda Hospital, Parnell Square, Dublin, 1, Ireland

    N. Purandare, G. Emerson, C. Kirkham & E. Mocanu

  2. Rotunda IVF, Parnell Square, Dublin, 1, Ireland

    N. Purandare, C. Harrity & D. Walsh

Authors
  1. N. Purandare
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  2. G. Emerson
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  3. C. Kirkham
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  4. C. Harrity
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  5. D. Walsh
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  6. E. Mocanu
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Corresponding author

Correspondence to N. Purandare.

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Declaration

No ethical approval was required due to the retrospective nature of the study.

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Purandare, N., Emerson, G., Kirkham, C. et al. The duration of gonadotropin stimulation does not alter the clinical pregnancy rate in IVF or ICSI cycles. Ir J Med Sci 186, 653–657 (2017). https://doi.org/10.1007/s11845-016-1526-3

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  • DOI: https://doi.org/10.1007/s11845-016-1526-3

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