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Correction of vitamin D deficiency in a cohort of newborn infants using daily 200 IU vitamin D supplementation

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Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

Abstract

Introduction

Although the role of vitamin D in the prevention of rickets has long been well established, controversies still exist on the ideal dose of vitamin D supplementation in infants.

Objective

We assessed serum 25-hydroxyvitamin D (25OHD) status simultaneously in maternal and cord samples and the response to vitamin D3 supplementation in neonates.

Methods

Serum 25OHD levels were evaluated from maternal, and umbilical cord samples from term normal pregnancies. Repeat 25OHD levels were assessed in neonates with 25OHD below 30 nmol/L following vitamin D3 200 IU daily after 6 weeks.

Results

Blood samples were taken including 57 cord samples and 16 follow-up neonatal samples. Maternal and cord serum 25OHD were 43 ± 21 and 29 ± 15 nmol/L, respectively. Infants with 25OHD < 30 nmol/L (19.8 ± 4.7 nmol/L) had a significant increase in serum 25OHD (63.3 ± 14.5 nmol/L) following vitamin D3 200 IU daily after 6 weeks.

Conclusion

Healthy Irish infants born at term are at high risk of vitamin D deficiency, but vitamin D3 200 IU daily, rapidly corrects poor vitamin D status.

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Author information

Authors and Affiliations

  1. Department of Neonatology, National Maternity Hospital, Dublin, Ireland

    C. Onwuneme, B. Diya, O. Uduma, R. A. McCarthy & E. J. Molloy

  2. Department of Paediatrics, Children’s University Hospital, Temple Street, Dublin, Ireland

    C. Onwuneme & N. Murphy

  3. Department of Medicine & Medical Sciences, University College Dublin, Dublin, Ireland

    C. Onwuneme, M. J. McKenna & E. J. Molloy

  4. Department of Metabolism and Endocrinology, St Vincent’s University Hospital, Dublin, Ireland

    M. T. Kilbane & M. J. McKenna

  5. Department of Paediatrics, Department of Paediatrics, Royal College of Surgeons of Ireland, Dublin, Ireland

    E. J. Molloy

  6. Department of Neonatology, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland

    E. J. Molloy

  7. Department of Paediatrics, Trinity College Dublin, Dublin, Ireland

    E. J. Molloy

  8. Department of Paediatrics, Trinity Centre for Health Sciences, Adelaide and Meath Hospital Dublin incorporating The National Children’s Hospital (AMNCH), Tallaght, Dublin 24, Ireland

    E. J. Molloy

Authors
  1. C. Onwuneme
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  2. B. Diya
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  3. O. Uduma
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  4. R. A. McCarthy
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  5. N. Murphy
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  6. M. T. Kilbane
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  7. M. J. McKenna
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  8. E. J. Molloy
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Corresponding author

Correspondence to C. Onwuneme.

Ethics declarations

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of interest

The authors declare no conflict of interest.

Funding

National Maternity Hospital Fund.

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Onwuneme, C., Diya, B., Uduma, O. et al. Correction of vitamin D deficiency in a cohort of newborn infants using daily 200 IU vitamin D supplementation. Ir J Med Sci 185, 683–687 (2016). https://doi.org/10.1007/s11845-015-1341-2

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  • DOI: https://doi.org/10.1007/s11845-015-1341-2

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