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The accuracy of magnetic resonance imaging in prostate cancer staging: a single-institution experience

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Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

Abstract

Background

Magnetic resonance imaging (MRI) has a wide reported variation in sensitivity and specificity for staging prostate cancer (PCA).

Aims

We examined the accuracy of MRI in detecting PCA, and in identifying extracapsular extension (ECE) and seminal vesicle invasion (SVI) in PCA patients at our institution.

Methods

We retrospectively reviewed pre-biopsy MRI findings and correlated the same with subsequent radical prostatectomy pathology reports in all patients undergoing radical prostatectomy between 2010 and 2012. Specifically, comparison was made between MRI and pathologic stage. Age, serum prostate-specific antigen level and Gleason score were recorded.

Results

MRI detected signal abnormalities in 50 out of 88 PCA patients undergoing radical prostatectomy. Of these, 12 had ECE and 7 had SVI on final histology. The sensitivity and specificity of MRI for detecting ECE were 75 and 100 %, respectively. The sensitivity and specificity of MRI for detecting SVI were 16.7 and 100 %, respectively. The positive predictive values for determining ECE and SVI were 100 % and negative predictive values were 96.2 and 90.6 %, respectively.

Conclusions

MRI may be reliable for excluding ECE and SVI in PCA patients where the lesion is visible on MRI. It has a good diagnostic ability for ECE, but is less accurate for identifying SVI. This article supports the use of MRI in the preoperative evaluation of PCA.

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Acknowledgments

We would like to acknowledge the Department of Diagnostic Imaging, in particular Dr Eamonn Carmody, Dr David Kidney, Dr Val Moran, Dr Jed Thompson, and the radiography team at the Bon Secours Hospital Cork. We also acknowledge our clinical audit analyst Jo O’Keefe all the Urology theatre and ward staff in the Department of Urology.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Bon Secours Hospital, Cork, Ireland

    S. F. Oon, S. P. Power, J. S. Kelly, V. McDermott, P. Ryan & P. C. Ryan

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  1. S. F. Oon
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  2. S. P. Power
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  3. J. S. Kelly
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  4. V. McDermott
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Correspondence to S. F. Oon.

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Oon, S.F., Power, S.P., Kelly, J.S. et al. The accuracy of magnetic resonance imaging in prostate cancer staging: a single-institution experience. Ir J Med Sci 184, 313–317 (2015). https://doi.org/10.1007/s11845-014-1109-0

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  • DOI: https://doi.org/10.1007/s11845-014-1109-0

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