JOM

, Volume 61, Issue 6, pp 12–16

Atomic layer deposition of TiO2 thin films on nanoporous alumina templates: Medical applications

Authors

    • Joint Department of Biomedical EngineeringUniversity of North Carolina and North Carolina State University
  • Nancy A. Monteiro-Riviere
    • Joint Department of Biomedical EngineeringUniversity of North Carolina and North Carolina State University
    • Center for Chemical Toxicology Research and PharmacokineticsNorth Carolina State University
  • Robin L. Brigmon
    • Savannah River National Laboratory
  • Michael J. Pellin
    • Materials Science DivisionArgonne National Laboratory
  • Jeffrey W. Elam
    • Energy Systems DivisionArgonne National Laboratory
Thin Films and Interfaces Overview

DOI: 10.1007/s11837-009-0081-z

Cite this article as:
Narayan, R.J., Monteiro-Riviere, N.A., Brigmon, R.L. et al. JOM (2009) 61: 12. doi:10.1007/s11837-009-0081-z

Abstract

Nanostructured materials may play a significant role in controlled release of pharmacologic agents for treatment of cancer. Many nanoporous polymer materials are inadequate for use in drug delivery. Nanoporous alumina provides several advantages over other materials for use in controlled drug delivery and other medical applications. Atomic layer deposition was used to coat all the surfaces of a nanoporous alumina membrane in order to reduce the pore size in a controlled manner. Neither the 20 nm nor the 100 nm TiO2-coated nanoporous alumina membranes exhibited statistically lower viability compared to the uncoated nanoporous alumina membrane control materials. Nanostructured materials prepared using atomic layer deposition may be useful for delivering a pharmacologic agent at a precise rate to a specific location in the body. These materials may serve as the basis for “smart” drug delivery devices, orthopedic implants, or self-sterilizing medical devices.

Copyright information

© TMS 2009