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The relationship between perioperative administration of inhaled corticosteroid and postoperative respiratory complications after pulmonary resection for non-small-cell lung cancer in patients with chronic obstructive pulmonary disease

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Abstract

Objectives

Inhaled corticosteroid (ICS) treatment has been shown to increase the risk of respiratory complications in patients with stable chronic obstructive pulmonary disease (COPD). However, the effects of perioperative ICS treatment on postoperative respiratory complications after lung cancer surgery have not been elucidated. The aim of this study was to investigate whether perioperative ICS treatment would increase the risk of postoperative respiratory complications after lung cancer surgery in patients with COPD.

Methods

We retrospectively analyzed 174 consecutive COPD patients with non-small-cell lung cancer (NSCLC) who underwent lobectomy or segmentectomy between January 2007 and December 2014. Subjects were grouped based on whether or not they were administered perioperative ICS treatment. Postoperative cardiopulmonary complications were compared between the groups.

Results

There were no statistically significant differences in the incidence of postoperative respiratory complications (P = 0.573) between the perioperative ICS treatment group (n = 16) and the control group (n = 158). Perioperative ICS treatment was not significantly associated with postoperative respiratory complications in the univariate or multivariate analysis (odds ratio [OR] = 0.553, 95 % confidence interval [CI] = 0.069–4.452, P = 0.578; OR = 0.635, 95 % CI = 0.065–6.158, P = 0.695, respectively). Kaplan–Meier analysis showed that there were no statistically significant differences in the postoperative respiratory complications-free durations between the groups (P = 0.566), even after propensity score matching (P = 0.551).

Conclusion

There was no relationship between perioperative ICS administration and the incidences of postoperative respiratory complications after surgical resection for NSCLC in COPD patients.

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Authors and Affiliations

  1. Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan

    Keiji Yamanashi, Satoshi Marumo, Takamasa Fukui, Ryota Sumitomo, Yosuke Otake, Minoru Sakuramoto, Motonari Fukui & Cheng-Long Huang

  2. Department of Thoracic Surgery, Japanese Red Cross Otsu Hospital, Shiga, Japan

    Tsuyoshi Shoji

Authors
  1. Keiji Yamanashi
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  2. Satoshi Marumo
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  3. Tsuyoshi Shoji
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  4. Takamasa Fukui
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  5. Ryota Sumitomo
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  6. Yosuke Otake
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  7. Minoru Sakuramoto
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  8. Motonari Fukui
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  9. Cheng-Long Huang
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Correspondence to Satoshi Marumo.

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The authors have declared that no conflict of interest exists.

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Yamanashi, K., Marumo, S., Shoji, T. et al. The relationship between perioperative administration of inhaled corticosteroid and postoperative respiratory complications after pulmonary resection for non-small-cell lung cancer in patients with chronic obstructive pulmonary disease. Gen Thorac Cardiovasc Surg 63, 652–659 (2015). https://doi.org/10.1007/s11748-015-0593-0

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  • DOI: https://doi.org/10.1007/s11748-015-0593-0

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