Lipids

, Volume 46, Issue 2, pp 105–119

The Health Promoting Properties of the Conjugated Isomers of α-Linolenic Acid

Authors

  • Alan A. Hennessy
    • TEAGASCMoorepark Food Research Centre
    • Alimentary Pharmabiotic Centre
  • R. Paul Ross
    • TEAGASCMoorepark Food Research Centre
    • Alimentary Pharmabiotic Centre
  • Rosaleen Devery
    • National Institute for Cellular BiotechnologyDublin City University
    • TEAGASCMoorepark Food Research Centre
    • Alimentary Pharmabiotic Centre
Review

DOI: 10.1007/s11745-010-3501-5

Cite this article as:
Hennessy, A.A., Ross, R.P., Devery, R. et al. Lipids (2011) 46: 105. doi:10.1007/s11745-010-3501-5

Abstract

The bioactive properties of the conjugated linoleic acid (CLA) isomers have long been recognised and are the subject of a number of excellent reviews. However, despite this prominence the CLA isomers are not the only group of naturally occurring dietary conjugated fatty acids which have shown potent bioactivity. In a large number of in vitro and in vivo studies, conjugated α-linolenic acid (CLNA) isomers have displayed potent anti-inflammatory, immunomodulatory, anti-obese and anti-carcinogenic activity, along with the ability to improve biomarkers of cardio-vascular health. CLNA isomers are naturally present in high concentrations in a large variety of seed oils but can also be produced in vitro by strains of lactobacilli and bifidobactena through the activity of the enzyme linoleic acid isomerase on α-linolenic acid. In this review, we will address the possible therapeutic roles that CLNA may play in a number of conditions afflicting Western society and the mechanisms through which this activity is mediated.

Keywords

CLACatalpicEleostearicCalendicPunicicCancerObesityAtherosclerosisInflammation

Abbreviations

CLNA

Conjugated α-linolenic acid

CLA

Conjugated linoleic acid

COX-2

Cyclooxygenase-2

HDL

High density lipoprotein

IFN-γ

Interferon-γ

Ig

Immunoglobulin

LDL

Low density lipoprotein

LETO

Long–Evans Tokusima Otsuka

NF-kB

Nuclear factor kappa B

OLETF

Otsuka Long Evans Tokushima Fatty

PPAR

Peroxisome proliferator-activated receptor

SREBP

Sterol regulatory element binding protein(s)

TAG

Triacylglycerol

TNF-α

Tumor necrosis factor α

VLDL

Very low density lipoprotein

Copyright information

© AOCS 2010