Original Article

Lipids

, Volume 44, Issue 12, pp 1125-1130

Effects of Weight Loss on Lipid Transfer Proteins in Morbidly Obese Women

  • Markus W. LaimerAffiliated withDepartment of Internal Medicine I, Medical University Innsbruck
  • , Julia EnglAffiliated withDepartment of Internal Medicine I, Medical University Innsbruck
  • , Alexander TschonerAffiliated withDepartment of Internal Medicine I, Medical University Innsbruck
  • , Susanne KaserAffiliated withDepartment of Internal Medicine I, Medical University Innsbruck
  • , Andreas RitschAffiliated withDepartment of Internal Medicine I, Medical University Innsbruck
  • , Tobias TatarczykAffiliated withDepartment of Internal Medicine I, Medical University Innsbruck
  • , Markus RauchenzaunerAffiliated withDepartment of Pediatrics, Medical University Innsbruck
  • , Helmut WeissAffiliated withDepartment of General Surgery, SJOG Hospital Salzburg
  • , Franz AignerAffiliated withDepartment of General, Thoracic and Transplant Surgery, Medical University Innsbruck
    • , Josef R. PatschAffiliated withDepartment of Internal Medicine I, Medical University Innsbruck
    • , Christoph F. EbenbichlerAffiliated withDepartment of Internal Medicine I, Medical University Innsbruck Email author 

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Abstract

Obesity is associated with lipid abnormalities leading to an increased morbidity and mortality from atherosclerotic disease. Lipid transfer proteins such as Cholesteryl Ester Transfer Protein (CETP) and Phospholipid Transfer Protein (PLTP), and lipases such as lipoprotein lipase (LPL) and hepatic lipase (HL) are involved in the pathogenesis of the obesity associated proatherogenic dyslipidemia. Nineteen severely obese female subjects undergoing laparosopic gastric banding participated in this prospective study. Subjects were examined with respect to body composition, lipid profile, CETP, PLTP, LPL and HL before and 1 year after surgical treatment. Mean weight loss was 22.2 kg, mainly due to losses in the fat depots. Triglycerides decreased and HDL2-C increased significantly. In respect to transfer proteins mean CETP mass decreased from 1.82 to 1.71 μg mL−1 (P = 0.043) and mean PLTP activity was reduced from 7.15 to 6.12 μmol mL−1 h−1 (P = 0.002), in parallel. In addition, both mean LPL activity and mean HL activity tended to decrease from 297 to 248 nmol mL−1 h−1 for LPL (P = 0.139) and from 371 to 319 nmol mL−1 h−1 for HL (P = 0.170), respectively. We conclude that weight loss induced by bariatric surgery is associated with the amelioration of the obesity-associated dyslipidemic state. This improvement may be attributable to decreased mass and action of the adipocyte tissue derived lipid transfer proteins CETP and PLTP.

Keywords

Weight loss Cholesteryl ester transfer protein Hepatic lipase Lipids Lipoprotein lipase Phospholipid transfer protein