Lipids

, 44:1125

Effects of Weight Loss on Lipid Transfer Proteins in Morbidly Obese Women

Authors

  • Markus W. Laimer
    • Department of Internal Medicine IMedical University Innsbruck
  • Julia Engl
    • Department of Internal Medicine IMedical University Innsbruck
  • Alexander Tschoner
    • Department of Internal Medicine IMedical University Innsbruck
  • Susanne Kaser
    • Department of Internal Medicine IMedical University Innsbruck
  • Andreas Ritsch
    • Department of Internal Medicine IMedical University Innsbruck
  • Tobias Tatarczyk
    • Department of Internal Medicine IMedical University Innsbruck
  • Markus Rauchenzauner
    • Department of PediatricsMedical University Innsbruck
  • Helmut Weiss
    • Department of General SurgerySJOG Hospital Salzburg
  • Franz Aigner
    • Department of General, Thoracic and Transplant SurgeryMedical University Innsbruck
  • Josef R. Patsch
    • Department of Internal Medicine IMedical University Innsbruck
    • Department of Internal Medicine IMedical University Innsbruck
Original Article

DOI: 10.1007/s11745-009-3349-8

Cite this article as:
Laimer, M.W., Engl, J., Tschoner, A. et al. Lipids (2009) 44: 1125. doi:10.1007/s11745-009-3349-8

Abstract

Obesity is associated with lipid abnormalities leading to an increased morbidity and mortality from atherosclerotic disease. Lipid transfer proteins such as Cholesteryl Ester Transfer Protein (CETP) and Phospholipid Transfer Protein (PLTP), and lipases such as lipoprotein lipase (LPL) and hepatic lipase (HL) are involved in the pathogenesis of the obesity associated proatherogenic dyslipidemia. Nineteen severely obese female subjects undergoing laparosopic gastric banding participated in this prospective study. Subjects were examined with respect to body composition, lipid profile, CETP, PLTP, LPL and HL before and 1 year after surgical treatment. Mean weight loss was 22.2 kg, mainly due to losses in the fat depots. Triglycerides decreased and HDL2-C increased significantly. In respect to transfer proteins mean CETP mass decreased from 1.82 to 1.71 μg mL−1 (P = 0.043) and mean PLTP activity was reduced from 7.15 to 6.12 μmol mL−1 h−1 (P = 0.002), in parallel. In addition, both mean LPL activity and mean HL activity tended to decrease from 297 to 248 nmol mL−1 h−1 for LPL (P = 0.139) and from 371 to 319 nmol mL−1 h−1 for HL (P = 0.170), respectively. We conclude that weight loss induced by bariatric surgery is associated with the amelioration of the obesity-associated dyslipidemic state. This improvement may be attributable to decreased mass and action of the adipocyte tissue derived lipid transfer proteins CETP and PLTP.

Keywords

Weight lossCholesteryl ester transfer proteinHepatic lipaseLipidsLipoprotein lipasePhospholipid transfer protein

Abbreviations

CE

Cholesteryl esters

CETP

Cholesteryl ester transfer protein

HDL

High density lipoprotein

HL

Hepatic lipase

LAGB

Laparoscopic adjustable gastric banding

LDL

Low density lipoprotein

LPL

Lipoprotein lipase

PLTP

Phospholipid transfer protein

VLDL

Very low-density lipoprotein

Copyright information

© AOCS 2009