Synthesis and Characterization of Novel Cationic Lipids Derived from Thio Galactose
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- Qiao, W., Zhou, M. & Luo, L. J Surfact Deterg (2014) 17: 261. doi:10.1007/s11743-013-1474-0
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Two double chain cationic lipids QAS Cn-2-S (n = 12, 14) derived from thio galactose and carbamate-linkage tertiary amine were synthesized and their structures were confirmed by MS, TOF-MS, 1H NMR and 13C NMR. The QAS C12-2-S revealed superior surface activity compared with QAS C14-2-S with lower CMC and γCMC. Though Lipo C12-2-S displayed large average particle-size with high polydispersity, positive charged Lipo Cn-2-S can be combined with the negative charged DNA, also negatively stained TEM images confirmed the formation of vesicles. All the above prove that the Lipo Cn-2-S is helpful for gene transfection.