Original Article

Journal of Surfactants and Detergents

, Volume 17, Issue 2, pp 261-268

Synthesis and Characterization of Novel Cationic Lipids Derived from Thio Galactose

  • Weihong QiaoAffiliated withState Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology Email author 
  • , Min ZhouAffiliated withState Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology
  • , Limei LuoAffiliated withState Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology

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Abstract

Two double chain cationic lipids QAS C n -2-S (n = 12, 14) derived from thio galactose and carbamate-linkage tertiary amine were synthesized and their structures were confirmed by MS, TOF-MS, 1H NMR and 13C NMR. The QAS C12-2-S revealed superior surface activity compared with QAS C14-2-S with lower CMC and γCMC. Though Lipo C12-2-S displayed large average particle-size with high polydispersity, positive charged Lipo C n -2-S can be combined with the negative charged DNA, also negatively stained TEM images confirmed the formation of vesicles. All the above prove that the Lipo C n -2-S is helpful for gene transfection.

Keywords

Synthesis Thio galactose Cationic lipids Vesicle