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Fecal calprotectin and ulcerative colitis endoscopic activity index as indicators of mucosal healing in ulcerative colitis

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Abstract

Ulcerative colitis (UC) is a chronic, idiopathic, inflammatory large bowel disease with recurrent variable periods of exacerbation. The aim of the current study is to evaluate the correlation of UCEIS with fecal calprotectin (FC) level to assess disease activity in UC patients in order to determine whether FC can prognosticate clinical outcome and disease activity of UC instead of colonoscopic evaluation. Our endoscopic investigations revealed the extension of UC as the following: proctitis (11.6 %), procto-sigmoiditis (18.5 %), left-sided colitis (15.8 %), extensive colitis (11.7 %), and normal endoscopy (42.4 %). Conclusively, we suggest that FC can be used as a reliable tool to evaluate disease activity in ulcerative colitis patients. Moreover, our findings indicate a significant correlation between FC level and mucosal healing.

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Authors and Affiliations

  1. Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Amir Mazandarani Street, 48166-33131, Sari, Iran

    Tarang Taghvaei, Iradj Maleki, Hafez Fakheri, Vahid Hosseini, Seyed Mohammad Valizadeh & Hassan Neishaboori

  2. Department of Pathology, Mazandaran University of Medical Sciences, Sari, Iran

    Farshad Nagshvar

Authors
  1. Tarang Taghvaei
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  2. Iradj Maleki
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  3. Farshad Nagshvar
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  4. Hafez Fakheri
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  5. Vahid Hosseini
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  6. Seyed Mohammad Valizadeh
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  7. Hassan Neishaboori
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Correspondence to Iradj Maleki.

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Taghvaei, T., Maleki, I., Nagshvar, F. et al. Fecal calprotectin and ulcerative colitis endoscopic activity index as indicators of mucosal healing in ulcerative colitis. Intern Emerg Med 10, 321–328 (2015). https://doi.org/10.1007/s11739-014-1144-x

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  • DOI: https://doi.org/10.1007/s11739-014-1144-x

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