, Volume 8, Issue 3, pp 265-267
Date: 25 Nov 2012

Hepatic Steatosis Index and Lipid Accumulation Product as middle-term predictors of incident metabolic syndrome in a large population sample: data from the Brisighella Heart Study

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Dear Editor,

Non-alcoholic fatty liver disease (NAFLD) is a pathologic condition characterized by the deposition of triglycerides (TG) in the liver >5 % of the total liver weight, in the presence of alcohol consumption <10 g daily, involving 20–30 % of the adult population in Western countries [1].

Progression of fatty liver to necroinflammation and fibrosis stages is not only a common cause of chronic liver disease but also a risk factor for increased all-cause mortality, type 2 diabetes and cardiovascular disease. The pathophysiological link among NAFLD, type 2 diabetes, and cardiovascular diseases seems to be insulin-resistance, which induces pathological ectopic fat accumulation combined with a low-grade chronic inflammatory state, in turn, resulting in abnormal glucose, altered fatty acid and lipoprotein metabolism, increased oxidative stress, deranged adipokine profile, hypercoagulability, endothelial dysfunction, and accelerated progression of atherosclerosis. This makes NAFLD the ...

On behalf of the Brisighella Heart Study.