Skip to main content

Advertisement

Log in

A practical approach to diagnosis and management of functional constipation in adults

  • IM - REVIEW
  • Published:
Internal and Emergency Medicine Aims and scope Submit manuscript

Abstract

Chronic constipation is a frequently complained condition in clinical practice and may be primary (idiopathic) or due to secondary causes. The definition of the various forms of constipation is presently made according to the Rome III criteria, which recently incorporated also specific diagnostic algorithms. The diagnosis of constipation relies on the patient’s history, including use of drugs, physical examination, and specific investigations (transit time, anorectal manometry, balloon expulsion test, defecography). These will often be useful to start a targeted therapeutic schedule that may include fibres, laxatives, biofeedback training and, in extreme cases, a surgical approach. This review will analyse the clinical and diagnostic aspects of chronic constipation in adult patients, with emphasis on recent therapeutic approaches.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Longstreth GF, Grant Thompson W, Chey WD, Houghton LA, Mearin F, Spiller RC (2006) Functional bowel disorders. Gastroenterology 130:1480–1491

    Article  PubMed  Google Scholar 

  2. Spiller RC, Thompson WG (2010) Bowel disorders. Am J Gastroenterol 105:775–785

    Article  PubMed  Google Scholar 

  3. Bellini M, Alduini P, Bassotti G, Bove A, Bocchini R, Sormani MP, Bruzzi P, Pucciani F, Italian Constipation StudyGroup (2006) Self-perceived normality in defecation habits. Dig Liver Dis 38:103–108

    PubMed  CAS  Google Scholar 

  4. Bassotti G, Carlani E, Baldoni M, Gullà N, Morozzi B, Villanacci V (2011) Painful constipation: a neglected entity? Rev Esp Enferm Dig 103:25–28

    Article  PubMed  CAS  Google Scholar 

  5. Heaton KW, O’Donnell LJ (1994) An office guide to whole-gut transit time patients’ recollection of their stool form. J Clin Gastroenterol 19:28–30

    Article  PubMed  CAS  Google Scholar 

  6. Müller-Lissner SA, Kamm MA, Scarpignato C, Wald A (2005) Myths and misconceptions about chronic constipation. Am J Gastroenterol 100:232–242

    Article  PubMed  Google Scholar 

  7. Eoff JC (2008) Optimal treatment of chronic constipation in managed care: review and roundtable discussion. J Manag Care Pharm 14((9 Suppl A)):1–15

    PubMed  Google Scholar 

  8. Agachan F, Chen T, Pfeifer J, Reissman P, Wexner SD (1996) A constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum 39:681–685

    Article  PubMed  CAS  Google Scholar 

  9. Solé LI, Bolino MC, Lueso M, Caro L, Cerisoli C, Castiglia N, Bassotti G (2009) Prevalence of sexual and physical abuse in patients with obstructed defecation: impact on biofeedback treatment. Rev Esp Enferm Dig 101:464–467

    Article  PubMed  Google Scholar 

  10. Cash BD, Schoenfeld P, Chey WD (2002) The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review. Am J Gastroenterol 97:2812–2819

    Article  PubMed  Google Scholar 

  11. Esfandyari T, Harewood GC (2007) Value of a negative colonoscopy in patients with non-specific gastrointestinal symptoms. J Gastroenterol Hepatol 22:1609–1614

    Article  PubMed  Google Scholar 

  12. Metcalf AM, Phillips SF, Zinsmeister AR, MacCarty RL, Beart RW, Wolff BG (1987) Simplified assessment of segmental colonic transit. Gastroenterology 92:40–47

    PubMed  CAS  Google Scholar 

  13. Chiarioni G, Whitehead WE, Pezza V, Morelli A, Bassotti G (2006) Biofeedback is superior to laxatives for normal transit constipation due to pelvic floor dyssynergia. Gastroenterology 130:657–664

    Article  PubMed  Google Scholar 

  14. Duthie GS, Bartolo DCC (1992) Anismus: the cause of constipation? Results of investigation and treatment. World J Surg 16:831–8355

    Article  PubMed  CAS  Google Scholar 

  15. Bassotti G, Stanghellini V, Chiarioni G, Germani U, De Giorgio R, Vantini I, Morelli A, Corinaldesi R (1996) Upper gastrointestinal motor activity in patients with slow-transit constipation. Further evidence for an enteric neuropathy. Dig Dis Sci 41:1999–2005

    Article  PubMed  CAS  Google Scholar 

  16. Bassotti G, Chiarioni G, Germani U, Battaglia E, Vantini I, Morelli A (1999) Endoluminal instillation of bisacodyl in patients with severe (slow transit type) constipation is useful to test residual colonic propulsive activity. Digestion 60:69–73

    Article  PubMed  CAS  Google Scholar 

  17. Bassotti G, Roberto GD, Sediari L, Morelli A (2004) Toward a definition of colonic inertia. World J Gastroenterol 10:2465–2246

    Google Scholar 

  18. Brennan D, Williams G, Kruskal J (2008) Practical performance of defecography for the evaluation of constipation and incontinence. Semin Ultrasound CT MR 29:420–426

    Article  PubMed  Google Scholar 

  19. Bassotti G (2000) Motions and emotions: the treatment of depression causes constipation. Neurogastroenterol Mot 12:113–115

    Article  CAS  Google Scholar 

  20. Yuan CS, Foss JF, O’Connor M, Toledano A, Roizen MF, Moss J (1996) Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial. Clin Pharmacol Ther 59:469–475

    Article  PubMed  CAS  Google Scholar 

  21. Simpson K, Leyendecker P, Hopp M, Müller-Lissner S, Löwenstein O, De Andrés J, Troy Ferrarons J, Bosse B, Krain B, Nichols T, Kremers W, Reimer K (2008) Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain. Curr Med Res Opin 24:3503–3512

    Article  PubMed  CAS  Google Scholar 

  22. Suares NC, Ford AC (2011) Systematic review: the effects of fibre in the management of chronic idiopathic constipation. Aliment PharmacolTher 33:895–901

    Article  CAS  Google Scholar 

  23. Corazziari E, Badiali D, Bazzocchi G, Bassotti G, Roselli P, Mastropaolo G, Lucà MG, Galeazzi R, Peruzzi E (2000) Long term efficacy, safety, and tolerability of low daily doses of isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in the treatment of functional chronic constipation. Gut 46:522–526

    Article  PubMed  CAS  Google Scholar 

  24. Lee-Robichaud H, Thomas K, Morgan J, Nelson RL (2010) Lactulose versus polyethylene glycol for chronic constipation. Cochrane Database Syst Rev 7:CD007570

    Google Scholar 

  25. Mueller-Lissner S, Kamm MA, Wald A, Hinkel U, Koehler U, Richter E, Bubeck J (2010) Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol 105:897–903

    Article  PubMed  CAS  Google Scholar 

  26. Camilleri M, Kerstens R, Rykx A, Vandeplassche L (2008) A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med 358:2344–2354

    Article  PubMed  CAS  Google Scholar 

  27. Barish CF, Drossman D, Johanson JF, Ueno R (2010) Efficacy and safety of lubiprostone in patients with chronic constipation. Dig Dis Sci 55:1090–1097

    Article  PubMed  CAS  Google Scholar 

  28. Taghavi SA, Shabani S, Mehramiri A, Eshraghian A, Kazemi SM, Moeini M, Hosseini-Asl SM, Saberifiroozi M, Alizade-Naeeni M, Mostaghni AA (2010) Colchicine is effective for short-term treatment of slow transit constipation: a double-blind placebo-controlled clinical trial. Int J Colorectal Dis 25:389–394

    Article  PubMed  Google Scholar 

  29. Bassotti G, Whitehead WE (1997) Biofeedback, relaxation training, and cognitive behaviour modification as treatments for lower functional gastrointestinal disorders. QJM 90:545–550

    Article  PubMed  CAS  Google Scholar 

  30. Maria G, Cadeddu F, Brandara F, Marniga G, Brisinda G (2006) Experience with type A botulinum toxin for treatment of outlet-type constipation. Am J Gastroenterol 101:2570–2575

    Article  PubMed  Google Scholar 

  31. Zehler O, Vashist YK, Bogoevski D, Bockhorn M, Yekebas EF, Izbicki JR, Kutup A (2010) Quo vadis STARR? A prospective long-term follow-up of stapled transanal rectal resection for obstructed defecation syndrome. J Gastrointest Surg 14:1349–1354

    Article  PubMed  Google Scholar 

  32. Tod AM, Stringer E, Levery C, Dean J, Brown J (2007) Rectal irrigation in the management of functional bowel disorders: a review. Br J Nurs 16:858–864

    PubMed  Google Scholar 

  33. Kapoor S (2008) Management of constipation in the elderly: emerging therapeutic strategies. World J Gastroenterol 14:5226–5227

    Article  PubMed  Google Scholar 

  34. Koch SM, Melenhorst J, van Gemert WG, Baeten CG (2008) Prospective study of colonic irrigation for the treatment of defaecation disorders. Br J Surg 95:1273–1279

    Article  PubMed  CAS  Google Scholar 

  35. Kamm MA, Dudding TC, Melenhorst J, Jarrett M, Wang Z, Buntzen S, Johansson C, Laurberg S, Rosen H, Vaizey CJ, Matzel K, Baeten C (2010) Sacral nerve stimulation for intractable constipation. Gut 59:333–340

    Article  PubMed  Google Scholar 

  36. Mollen RM, Kuijpers HC, Claassen AT (2001) Colectomy for slow-transit constipation: preoperative functional evaluation is important but not a guarantee for a successful outcome. Dis Colon Rectum 44:577–580

    Article  PubMed  CAS  Google Scholar 

  37. Wald A (2008) Management and prevention of fecal impaction. Curr Gastroenterol Rep 10:499–501

    Article  PubMed  Google Scholar 

  38. Eitan A, Bickel A, Katz IM (2006) Fecal impaction in adults: report of 30 cases of seed bezoars in the rectum. Dis Colon Rectum 49:1768–1771

    Article  PubMed  Google Scholar 

  39. Banov L Jr (1965) Proctology in ancient Egypt: its continuing influence on the management of anorectal diseases. South Med J 58:1366–1369

    Article  PubMed  Google Scholar 

  40. Chen CC, Su MY, Tung SY, Chang FY, Wong JM, Geraint M (2005) Evaluation of polyethylene glycol plus electrolytes in the treatment of severe constipation and faecal impaction in adults. Curr Med Res Opin 21:1595–1602

    Article  PubMed  CAS  Google Scholar 

  41. Cullen G, O’Donoghue D (2007) Constipation and pregnancy. Best Pract Res Clin Gastroenterol 21:807–818

    Article  PubMed  Google Scholar 

  42. Acs N, Bánhidy F, Puhó EH, Czeizel AE (2010) No association between severe constipation with related drug treatment in pregnant women and congenital abnormalities in their offspring: a population-based case-control study. Congenit Anom (Kyoto) 50:15–20

    Article  Google Scholar 

  43. van Tilburg MA, Palsson OS, Levy RL, Feld AD, Turner MJ, Drossman DA, Whitehead WE (2008) Complementary and alternative medicine use and cost in functional bowel disorders: a six month prospective study in a large HMO. BMC Complement Altern Med 8:46

    Google Scholar 

  44. Picon PD, Picon RV, Costa AF, Sander GB, Amaral KM, Aboy AL, Henriques AT (2010) Randomized clinical trial of a phytotherapic compound containing Pimpinellaanisum, Foeniculumvulgare, Sambucusnigra, and Cassia augustifolia for chronic constipation. BMC Complement Altern Med 10:17

    Google Scholar 

  45. Lin LW, Fu YT, Dunning T, Zhang AL, Ho TH, Duke M, Lo SK (2009) Efficacy of traditional Chinese medicine for the management of constipation: a systematic review. J Altern Complement Med 15:1335–1346

    Article  PubMed  Google Scholar 

  46. Goldberg M, Li YP, Johanson JF, Mangel AW, Kitt M, Beattie DT, Kersey K, Daniels O (2010) Clinical trial: the efficacy and tolerability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation—a 4-week, randomized, double-blind, placebo-controlled, dose-response study. Aliment Pharmacol Ther 32:1102–1112

    Article  PubMed  CAS  Google Scholar 

  47. Ford AC, Suares NC (2011) Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis. Gut 60:209–218

    Article  PubMed  Google Scholar 

  48. Bassotti G, Villanacci V, Maurer CA, Fisogni S, Di Fabio F, Cadei M, Morelli A, Panagiotis T, Cathomas G, Salerni B (2006) The role of glial cells and apoptosis of enteric neurones in the neuropathology of intractable slow transit constipation. Gut 55:41–46

    Article  PubMed  CAS  Google Scholar 

  49. Bassotti G, Villanacci V (2006) Slow transit constipation: a functional disorder becomes an enteric neuropathy. World J Gastroenterol 12:4609–4613

    PubMed  Google Scholar 

  50. Bassotti G, Villanacci V (2011) Can “functional” constipation be considered as a form of neuro-gliopathy? Glia 59:345–350

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gabrio Bassotti.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bassotti, G., Villanacci, V. A practical approach to diagnosis and management of functional constipation in adults. Intern Emerg Med 8, 275–282 (2013). https://doi.org/10.1007/s11739-011-0698-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11739-011-0698-0

Keywords

Navigation