Effect of ginger-partitioned moxibustion on immunocytokines in patients with chronic nonbacterial prostatitis

Abstract

Objective

To observe the effect of ginger-partitioned moxibustion on immunocytokines in patients with chronic nonbacterial prostatitis (CNP).

Methods

A total of 80 CNP patients were randomly allocated into two groups according to their visiting sequence, 40 cases in each group. Cases in the observation group were treated with oral Tamsulosin Hydrochloride Sustained Release Capsules (Harnal) (0.2 mg for each dose, one dose a day) and ginger-partitioned moxibustion at Qihai (CV 6), Guanyuan (CV 4), Zhongji (CV 3) and bilateral Zusanli (ST 36), Sanyinjiao (SP 6), Pangguangshu (BL 28), Shangliao (BL 31), Ciliao (BL 32), Zhongliao (BL 33) and Xialiao (BL 34) (once a day). Cases in the control group were treated with the oral Western medication alone (same administration as those in the observation group). Cases in both groups were treated for 28 d. Before and after treatment, the CD3⁺, CD4⁺, CD8⁺, CD4⁺ CD25⁺, CD4⁺ CD25⁺ Foxp3⁺, transforming growth factor (TGF )-β1, immunoglobulin (Ig) A, IgE, IgG and IgM were detected and scored using National Institutes of Health chronic prostatitis symptom index (NIH-CPSI).

Results

The total effective rate was 90.0% in the observation group, versus 72.5% in the control group, showing a statistical difference (P<0.05). After treatment, the CD3⁺, CD4⁺, CD8⁺, CD4⁺ CD25⁺, CD4⁺ CD25⁺ Foxp3⁺, TGF-β1, IgA, IgG and IgM were significantly increased in both groups, showing statistical differences (P<0.05). There were between-group statistical differences in CD3⁺, CD4⁺, CD8⁺, CD4⁺ CD25⁺, CD4⁺ CD25⁺ Foxp3⁺, TGF-β1, IgA, IgG, IgE, IgM, total NIH-CPSI score and pain and discomfort score (P<0.05).

Conclusion

Ginger-partitioned moxibustion can improve clinical symptoms of CNP patients by improving their immune function.

摘要

目的

观察隔姜灸对慢性非细菌性前列腺炎患者免疫细胞因子的影响。

方法

将慢性非细菌性前列腺炎患者80例, 按就诊顺序随机分为两组, 每组40例。 观察组予口服盐酸坦索罗辛缓释胶囊(哈乐)(Tamsulosin Hydrochloride Sustained Release Capsules, Harnal), 每次0.2mg, 每日1次; 隔姜灸气海、 关元、 中极及双侧足三里、 三阴交、 膀胱俞、 上髎、 次髎、 中髎和下髎治疗, 每日1次。 对照组仅口服盐酸坦索罗辛缓释胶囊, 剂量及服用方法与观察组相同。 两组均治疗28 d。 治疗前、 后检测患者外周血中CD3⁺、 CD4⁺、 CD8⁺、 CD4⁺ CD25⁺、 CD4⁺ CD25⁺ Foxp3⁺、 转化生长因子-β1 (transforming growth factor-β1, TGF-β1)、 免疫球蛋白(immuneglobulin, Ig) A、 IgE、 IgG和IgM, 并进行美国国立卫生研究院慢性前列腺炎症状指数(National Institutes of Health chronic prostatitis symptom index, NIH-CPSI)评分。

结果

观察组总有效率90.0%; 对照组总有效率72.5%, 两组总有效率差异有统计学意义(P<0.05)。 治疗后, 两组患者CD3⁺、 CD4⁺、 CD8⁺、 CD4⁺ CD25⁺、 CD4⁺ CD25⁺ Foxp3⁺、 TGF-β1、 IgA、 IgG及IgM均明显提高, 与本组治疗前差异有统计学意义(P<0.05); 观察组CD3⁺、 CD4⁺、 CD8⁺、 CD4⁺ CD25⁺、 CD4⁺ CD25⁺ Foxp3⁺、 TGF-β1、 IgA、 IgG、 IgE、 IgM、 NIH-CPSI总分及疼痛与不适评分与对照组有统计学差异(P<0.05)。

结论

隔姜灸可通过提高免疫功能改善慢性非细菌性前列腺炎患者的临床症状。