Frontiers of Materials Science

, Volume 6, Issue 3, pp 236–249

Gold nanoparticles: sonocatalytic synthesis using ethanolic extract of Andrographis paniculata and functionalization with polycaprolactone-gelatin composites

Authors

  • Punuri Jayasekhar Babu
    • Biomaterials and Tissue Engineering Laboratory, Department of BiotechnologyIndian Institute of Technology Guwahati
    • Biotech Hub, Centre for the EnvironmentIndian Institute of Technology Guwahati
  • Sibyala Saranya
    • Biotech Hub, Centre for the EnvironmentIndian Institute of Technology Guwahati
    • Department of BiotechnologyD.R.W. College, Gudur, SPS Nellore
  • Pragya Sharma
    • Biotech Hub, Centre for the EnvironmentIndian Institute of Technology Guwahati
  • Ranjan Tamuli
    • Biotech Hub, Centre for the EnvironmentIndian Institute of Technology Guwahati
    • Biomaterials and Tissue Engineering Laboratory, Department of BiotechnologyIndian Institute of Technology Guwahati
    • Biotech Hub, Centre for the EnvironmentIndian Institute of Technology Guwahati
Research Article

DOI: 10.1007/s11706-012-0175-3

Cite this article as:
Babu, P.J., Saranya, S., Sharma, P. et al. Front. Mater. Sci. (2012) 6: 236. doi:10.1007/s11706-012-0175-3

Abstract

Gold nanoparticles (AuNPs) were synthesized by sonication using ethanolic leaf extract of Andrographis paniculata. We investigated the optimum parameters for AuNP synthesis and functionalization with polycaprolactone-gelatin (PCL-GL) composites. The AuNPs were characterized with various biophysical techniques such as TEM, XRD, FT-IR and EDX spectroscopy. TEM images showed that nanoparticles were spherical in shape with a size range from 5 to 75 nm. EDX analysis revealed the presence of molecular oxygen and carbon on the surface of AuNPs. The synthesized AuNPs were tested for their effect on HeLa (human cervical cancer) and MCF-7 (human breast cancer) cell lines and found to be nontoxic and biocompatible, which are potential carriers for hydrophobic drugs.

Keywords

sonocatalasis Andrographis paniculata functionalization crystal growth biomaterial PCL-GL composite

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2012