Research Article

Frontiers of Materials Science

, Volume 6, Issue 3, pp 236-249

Gold nanoparticles: sonocatalytic synthesis using ethanolic extract of Andrographis paniculata and functionalization with polycaprolactone-gelatin composites

  • Punuri Jayasekhar BabuAffiliated withBiomaterials and Tissue Engineering Laboratory, Department of Biotechnology, Indian Institute of Technology GuwahatiBiotech Hub, Centre for the Environment, Indian Institute of Technology Guwahati
  • , Sibyala SaranyaAffiliated withBiotech Hub, Centre for the Environment, Indian Institute of Technology GuwahatiDepartment of Biotechnology, D.R.W. College, Gudur, SPS Nellore
  • , Pragya SharmaAffiliated withBiotech Hub, Centre for the Environment, Indian Institute of Technology Guwahati
  • , Ranjan TamuliAffiliated withBiotech Hub, Centre for the Environment, Indian Institute of Technology Guwahati
  • , Utpal BoraAffiliated withBiomaterials and Tissue Engineering Laboratory, Department of Biotechnology, Indian Institute of Technology GuwahatiBiotech Hub, Centre for the Environment, Indian Institute of Technology Guwahati Email author 

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Abstract

Gold nanoparticles (AuNPs) were synthesized by sonication using ethanolic leaf extract of Andrographis paniculata. We investigated the optimum parameters for AuNP synthesis and functionalization with polycaprolactone-gelatin (PCL-GL) composites. The AuNPs were characterized with various biophysical techniques such as TEM, XRD, FT-IR and EDX spectroscopy. TEM images showed that nanoparticles were spherical in shape with a size range from 5 to 75 nm. EDX analysis revealed the presence of molecular oxygen and carbon on the surface of AuNPs. The synthesized AuNPs were tested for their effect on HeLa (human cervical cancer) and MCF-7 (human breast cancer) cell lines and found to be nontoxic and biocompatible, which are potential carriers for hydrophobic drugs.

Keywords

sonocatalasis Andrographis paniculata functionalization crystal growth biomaterial PCL-GL composite