Frontiers of Materials Science

, Volume 6, Issue 3, pp 236–249

Gold nanoparticles: sonocatalytic synthesis using ethanolic extract of Andrographis paniculata and functionalization with polycaprolactone-gelatin composites

  • Punuri Jayasekhar Babu
  • Sibyala Saranya
  • Pragya Sharma
  • Ranjan Tamuli
  • Utpal Bora
Research Article

DOI: 10.1007/s11706-012-0175-3

Cite this article as:
Babu, P.J., Saranya, S., Sharma, P. et al. Front. Mater. Sci. (2012) 6: 236. doi:10.1007/s11706-012-0175-3

Abstract

Gold nanoparticles (AuNPs) were synthesized by sonication using ethanolic leaf extract of Andrographis paniculata. We investigated the optimum parameters for AuNP synthesis and functionalization with polycaprolactone-gelatin (PCL-GL) composites. The AuNPs were characterized with various biophysical techniques such as TEM, XRD, FT-IR and EDX spectroscopy. TEM images showed that nanoparticles were spherical in shape with a size range from 5 to 75 nm. EDX analysis revealed the presence of molecular oxygen and carbon on the surface of AuNPs. The synthesized AuNPs were tested for their effect on HeLa (human cervical cancer) and MCF-7 (human breast cancer) cell lines and found to be nontoxic and biocompatible, which are potential carriers for hydrophobic drugs.

Keywords

sonocatalasisAndrographis paniculatafunctionalizationcrystal growthbiomaterialPCL-GL composite

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Punuri Jayasekhar Babu
    • 1
    • 2
  • Sibyala Saranya
    • 2
    • 3
  • Pragya Sharma
    • 2
  • Ranjan Tamuli
    • 2
  • Utpal Bora
    • 1
    • 2
  1. 1.Biomaterials and Tissue Engineering Laboratory, Department of BiotechnologyIndian Institute of Technology GuwahatiGuwahatiIndia
  2. 2.Biotech Hub, Centre for the EnvironmentIndian Institute of Technology GuwahatiGuwahatiIndia
  3. 3.Department of BiotechnologyD.R.W. College, Gudur, SPS NelloreAndhraIndia