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Effects of Bariatric Surgery on Non-alcoholic Fatty Liver Disease: Magnetic Resonance Imaging Is an Effective, Non-invasive Method to Evaluate Changes in the Liver Fat Fraction

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Abstract

Introduction

Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease worldwide and is highly associated with obesity. The prevalences of both conditions have markedly increased in the Western civilization. Bariatric surgery is the most effective treatment for morbid obesity and its comorbidities such as NAFLD.

Objectives

Measure postoperative liver fat fraction (LFF) in bariatric patients by using in-opposed-phase MRI, a widely available clinical tool validated for the quantification of liver fat

Methods

Retrospective analyses of participants, who underwent laparoscopic Roux-Y-gastric-bypass (17) or laparoscopic sleeve gastrectomy (2) were performed using magnetic resonance imaging (MRI), bioelectrical impedance analysis (BIA), and anthropometric measurements 1 day before surgery, as well as 6, 12, and 24 weeks after surgery, LFF was calculated from fat-only and water-only MR images.

Results

Six months after surgery, a significant decrease of LFF and liver volume has been observed along with weight loss, decreased waist circumference, and parameters obtained by body fat measured by BIA. LFF significantly correlated with liver volume in the postoperative course.

Conclusions

MRI including in-opposed-phase imaging of the liver can detect the quantitative decrease of fatty infiltration within the liver after bariatric surgery and thus could be a valuable tool to monitor NAFLD/NASH postoperatively.

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Author information

Authors and Affiliations

  1. University Hospital of Cologne, Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany

    Dennis M. Hedderich & Stefan Haneder

  2. Department of Surgery, Alfried Krupp Krankhenhaus, Hellweg 100, 45276, Essen, Germany

    Till Hasenberg

  3. Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany

    Stefan O. Schoenberg

  4. Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, Germany

    Özlem Kücükoglu & Ali Canbay

  5. Department of Surgery, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany

    Mirko Otto

Authors
  1. Dennis M. Hedderich
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  2. Till Hasenberg
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  3. Stefan Haneder
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  4. Stefan O. Schoenberg
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  5. Özlem Kücükoglu
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  6. Ali Canbay
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  7. Mirko Otto
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Corresponding author

Correspondence to Till Hasenberg.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Statement of Informed Consent

Informed consent was obtained from all individual participants included in the study.

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None.

Additional information

Dennis Hedderich and Till Hasenberg contributed equally to this publication

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Hedderich, D.M., Hasenberg, T., Haneder, S. et al. Effects of Bariatric Surgery on Non-alcoholic Fatty Liver Disease: Magnetic Resonance Imaging Is an Effective, Non-invasive Method to Evaluate Changes in the Liver Fat Fraction. OBES SURG 27, 1755–1762 (2017). https://doi.org/10.1007/s11695-016-2531-3

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  • DOI: https://doi.org/10.1007/s11695-016-2531-3

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