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Comparing the Effectiveness of Total Gastrectomy and Gastric Bypass on Glucose Metabolism in Diabetic Rats

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Abstract

Background

Bariatric surgeries have been widely used in obesity associated type II diabetes. However, the mechanisms of surgical treatments for type II diabetes in non-obese patients remain controversial. Our study aims to compare the effectiveness of various bariatric surgeries in a non-obese diabetic rat model.

Methods

Goto-Kakisaki (GK) rats were used to compare the outcome of total gastrectomy (TG), Roux-en-Y reconstruction after total gastrectomy (RYTG), and Roux-En-Y gastric bypass (RYGB). Body weight, food and water intake, and glucose level were monitored prior to and after surgery. Oral glucose tolerance tests (OGTT) were performed, and key metabolic hormones were measured at selected time points.

Results

Despite a significant reduction in body weight in TG and RYTG groups, their glucose metabolic rate was not improved. RYGB rats, with only moderate reduction in food intake and body weight, had significantly improved glucose metabolism. Insulin and ghrelin were significantly reduced in TG and RYTG groups, but remained unchanged in RYGB group.

Conclusions

Our study demonstrated the effectiveness of RYGB surgery in treating type II diabetes in non-obese diabetic rats. These results suggest an important role of gastric system in regulating glucose homeostasis.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All applicable institutional and/or national guidelines for the care and use of animals were followed.

Informed Consent

Informed consent does not apply in this study.

Funding

The study was supported by the Natural Science Foundation of Shanghai Municipal Commission of Health and Family Planning, 20124293.

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Author notes

    Authors and Affiliations

    1. Department of General Surgery, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China

      Donglei Zhou, Xun Jiang, Wei Jian, Lijun Zheng & Liesheng Lu

    2. Department of General Surgery, Changhai Hospital of the Second Military Medical University, Shanghai, China

      Chengzhu Zheng

    Authors
    1. Donglei Zhou
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    2. Xun Jiang
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    3. Wei Jian
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    4. Lijun Zheng
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    5. Liesheng Lu
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    6. Chengzhu Zheng
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    Corresponding authors

    Correspondence to Liesheng Lu or Chengzhu Zheng.

    Additional information

    Donglei Zhou and Xun Jiang contributed equally to this work.

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    Zhou, D., Jiang, X., Jian, W. et al. Comparing the Effectiveness of Total Gastrectomy and Gastric Bypass on Glucose Metabolism in Diabetic Rats. OBES SURG 26, 119–125 (2016). https://doi.org/10.1007/s11695-015-1730-7

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    • DOI: https://doi.org/10.1007/s11695-015-1730-7

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