Obesity Surgery

, Volume 24, Issue 9, pp 1499–1509

Incidence of Cancer Following Bariatric Surgery: Systematic Review and Meta-analysis

  • Daniela Schaan Casagrande
  • Daniela Dornelles Rosa
  • Daniel Umpierre
  • Roberta Aguiar Sarmento
  • Clarissa Garcia Rodrigues
  • Beatriz D. Schaan
Review Article

DOI: 10.1007/s11695-014-1276-0

Cite this article as:
Casagrande, D.S., Rosa, D.D., Umpierre, D. et al. OBES SURG (2014) 24: 1499. doi:10.1007/s11695-014-1276-0

Abstract

Obesity is linked to the development of cancer. Previous studies have suggested that there is a relationship between bariatric surgery and reduced cancer risk. Data sources were from Medline, Embase, and Cochrane Library. From 951 references, 13 studies met the inclusion criteria (54,257 participants). In controlled studies, bariatric surgery was associated with a reduction in the risk of cancer. The cancer incidence density rate was 1.06 cases per 1000 person-years within the surgery groups. In the meta-regression, we found an inverse relationship between the presurgical body mass index and cancer incidence after surgery (beta coefficient −0.2, P < 0.05). Bariatric surgery is associated with reduced cancer risk in morbidly obese people. However, considering the heterogeneity among the studies, conclusions should be drawn with care.

Keywords

CancerMorbid obesityBariatric surgeryGastric bypass

Supplementary material

11695_2014_1276_MOESM1_ESM.docx (13 kb)
ESM 1(DOCX 12 kb)

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Daniela Schaan Casagrande
    • 1
    • 2
  • Daniela Dornelles Rosa
    • 3
  • Daniel Umpierre
    • 4
  • Roberta Aguiar Sarmento
    • 1
  • Clarissa Garcia Rodrigues
    • 5
    • 6
  • Beatriz D. Schaan
    • 1
    • 4
  1. 1.Postgraduate Program in Medical Sciences: Endocrinology and Metabolism, Universidade Federal do Rio Grande do SulHospital de Clínicas de Porto AlegrePorto AlegreBrazil
  2. 2.Obesity and Metabolic Syndrome Center of Hospital São LucasPontifícia Universidade Católica do Rio Grande do Sul (COM HSL-PUCRS)Porto AlegreBrazil
  3. 3.Oncology UnitHospital Moinhos de VentoPorto AlegreBrazil
  4. 4.Postgraduate Program in Health Sciences: Cardiovascular Sciences, Universidade Federal do Rio Grande do SulHospital de Clinicas de Porto AlegrePorto AlegreBrazil
  5. 5.Fundação Universitária de CardiologiaInstituto de Cardiologia do Rio Grande do Sul (IC-FUC)Porto AlegreBrazil
  6. 6.Duke Global Health Institute (DGHI)Duke UniversityDurhamUSA