Review Article

Obesity Surgery

, Volume 24, Issue 9, pp 1499-1509

Incidence of Cancer Following Bariatric Surgery: Systematic Review and Meta-analysis

  • Daniela Schaan CasagrandeAffiliated withPostgraduate Program in Medical Sciences: Endocrinology and Metabolism, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto AlegreObesity and Metabolic Syndrome Center of Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (COM HSL-PUCRS)
  • , Daniela Dornelles RosaAffiliated withOncology Unit, Hospital Moinhos de Vento
  • , Daniel UmpierreAffiliated withPostgraduate Program in Health Sciences: Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre
  • , Roberta Aguiar SarmentoAffiliated withPostgraduate Program in Medical Sciences: Endocrinology and Metabolism, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre
  • , Clarissa Garcia RodriguesAffiliated withFundação Universitária de Cardiologia, Instituto de Cardiologia do Rio Grande do Sul (IC-FUC)Duke Global Health Institute (DGHI), Duke University
  • , Beatriz D. SchaanAffiliated withPostgraduate Program in Medical Sciences: Endocrinology and Metabolism, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto AlegrePostgraduate Program in Health Sciences: Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre Email author 

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Abstract

Obesity is linked to the development of cancer. Previous studies have suggested that there is a relationship between bariatric surgery and reduced cancer risk. Data sources were from Medline, Embase, and Cochrane Library. From 951 references, 13 studies met the inclusion criteria (54,257 participants). In controlled studies, bariatric surgery was associated with a reduction in the risk of cancer. The cancer incidence density rate was 1.06 cases per 1000 person-years within the surgery groups. In the meta-regression, we found an inverse relationship between the presurgical body mass index and cancer incidence after surgery (beta coefficient −0.2, P < 0.05). Bariatric surgery is associated with reduced cancer risk in morbidly obese people. However, considering the heterogeneity among the studies, conclusions should be drawn with care.

Keywords

Cancer Morbid obesity Bariatric surgery Gastric bypass