Vagal Sparing Surgical Technique but Not Stoma Size Affects Body Weight Loss in Rodent Model of Gastric Bypass
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The aim of this study was to evaluate whether gastric bypass with or without vagal preservation resulted in a different outcome.
Body weight, food intake and postprandial peptide YY (PYY) and glucagon-like peptide (GLP-1) levels were compared between gastric bypass (n = 55) and sham-operated rats (n = 27) in three groups. In group 1 (n = 17), the vagal nerve was not preserved, while in group 2 the vagal nerve was preserved during gastric bypass (n = 10). In group 3, gastric bypass rats (n = 28) were randomised for either one of the two techniques.
Rats in which the vagal nerve was preserved during gastric bypass showed a lower body weight (p < 0.001) and reduced food intake (p < 0.001) compared to rats in which the vagal nerve was not preserved during the gastric bypass operation. Levels of PYY and GLP-1 were significantly increased after gastric bypass compared to sham-operated controls (p < 0.05), but there was no difference between gastric bypass rats with and without vagal preservation. Differences in food intake and body weight were not related to the size of the gastro-jejunostomy in gastric bypass rats. There were no signs of malabsorption or inflammation after gastric bypass.
We propose that the vagal nerve should be preserved during the gastric bypass operation as this might play an important role for the mechanisms that induce weight loss and reduce food intake in rats. In contrast, the gastro-jejunal stoma size was found to be of minor relevance.
- Vagal Sparing Surgical Technique but Not Stoma Size Affects Body Weight Loss in Rodent Model of Gastric Bypass
Volume 20, Issue 5 , pp 616-622
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Gastric bypass
- Para-oesophageal bundle
- Vagal nerve
- Left gastric vessels
- Weight loss
- Industry Sectors
- Author Affiliations
- 1. Imperial Weight Centre, Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, Du Cane Road, London, W12 0NN, UK
- 2. Department of Surgery, University of Würzburg, Würzburg, Germany
- 3. Institute of Veterinary Physiology and Zürich Centre for Integrative Human Physiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
- 4. Swiss Federal Institute of Technology, Physiology and Behavior Group, Schwerzenbach, Switzerland