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Changes in Oxidative Stress and Insulin Resistance in Morbidly Obese Patients After Bariatric Surgery

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Abstract

Background

The prevalence of morbid obesity has seen an increase in developed countries over recent years. Bariatric surgery is almost the only effective strategy for treating super morbidly obese patients. The objective of the study was to evaluate the effects of bariatric surgery on the evolution of the main variables related to diabetes and obesity, especially insulin resistance, parameters of oxidative stress, and inflammatory markers in the early stage after surgery.

Methods

The study was undertaken in 17 morbidly obese persons who were scheduled for biliopancreatic diversion of Scopinaro. Measurements were made before surgery and 15, 30, 45, and 90 days after surgery.

Results

We found that significant metabolic changes occurred during the first 90 days after bariatric surgery. The most significant decrease in insulin resistance occurred 15 days after the operation. At this point, the lipid profile and inflammatory and oxidative stress parameters had not improved. One month after surgery, insulin resistance had a parallel evolution to weight and the molecules directly associated with hypertrophic adipose tissue.

Conclusions

We suggest that there are two mechanisms that contribute to the improvement in insulin resistance after biliopancreatic diversion: on the one hand, a short-term effect related to gastric bypass, and on the other hand, a long-term effect from decreased fat mass and resulting changes in the release of molecules directly associated with hypertrophic adipose tissue.

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Acknowledgments

This work was supported in part by a grant from the Instituto de Salud Carlos III (CP04/00133) and Servicio Andaluz de Salud (0438/2006). CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03) is an ISCIII project. Murri is recipient of a predoctoral grant of Investigator Personal Formation (BES-2007-16594) from the Spanish Ministry of Education and Science. The authors thank Carlos Clue and Ana Bueno. The authors also thank Ian Johnstone for the English language version of the text.

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Servicio de Endocrinología y Nutrición, Campus Teatinos s/n, Hospital Clínico Universitario Virgen de la Victoria, 29010, Málaga, Spain

    Mora Murri, Eduardo García-Fuentes, José Manuel García-Almeida, Lourdes Garrido-Sánchez, María Dolores Mayas & Francisco J. Tinahones

  2. Laboratorio de Investigaciones Biomédicas, Fundación IMABIS, 1ª planta, 29010, Málaga, Spain

    Mora Murri & Eduardo García-Fuentes

  3. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBER, CB06/003), Instituto de Salud Carlos III, 29010, Málaga, Spain

    Eduardo García-Fuentes, Lourdes Garrido-Sánchez, María Dolores Mayas, Rosa Bernal & Francisco J. Tinahones

Authors
  1. Mora Murri
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  2. Eduardo García-Fuentes
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  3. José Manuel García-Almeida
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  4. Lourdes Garrido-Sánchez
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  5. María Dolores Mayas
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  6. Rosa Bernal
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  7. Francisco J. Tinahones
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Corresponding author

Correspondence to Eduardo García-Fuentes.

Additional information

Murri M. and Garcia Fuentes E. contributed equally to this work.

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Murri, M., García-Fuentes, E., García-Almeida, J.M. et al. Changes in Oxidative Stress and Insulin Resistance in Morbidly Obese Patients After Bariatric Surgery. OBES SURG 20, 363–368 (2010). https://doi.org/10.1007/s11695-009-0021-6

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  • DOI: https://doi.org/10.1007/s11695-009-0021-6

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