The comparative effects of bariatric surgery on weight and type 2 diabetes
- Pierre LevyAffiliated withLEGOS, University of Paris Dauphine Email author
- , Martin FriedAffiliated withClinical Center for Minimally Invasive and Bariatric Surgery — ISCARE, and 1st Medical Faculty, Charles University Prague
- , Ferruccio SantiniAffiliated withDepartment of Endocrinology and Metabolic Diseases, Pisa University Hospital
- , Nick FinerAffiliated withWellcome Trust Clinical Research Facility, Addenbrooke’s Hospital
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Background: Epidemiological evidence confirms that risk of developing type 2 diabetes is related to weight gain. Weight reduction is beneficial as relative risk is reduced to 0.13 for weight loss >20 kg. This raises the question of effectiveness of bariatric surgery on 1) weight loss and 2) diabetes-related outcomes in morbidly obese patients.
Methods: We reviewed the literature using Medline. Only 2 meta-analyses reporting on both outcomes were included, as well as 50 systematic reviews or primary studies.
Results: Meta-analyses mainly based on case series data as well as controlled studies confirm that bariatric surgery is highly effective in obtaining weight reduction in morbidly obese patients up to 60% of the excess weight, along with resolution of preoperative diabetes in more than 75% of cases. Among bariatric surgery techniques, malabsorptive procedures (biliopancreatic diversion and gastric bypass) appear to be more effective on both outcomes than restrictive procedures (gastroplasty and gastric banding).
Conclusion: Even if more studies are needed to confirm current evidence, bariatric surgery is effective for controlling diabetes. It appears as an efficient strategy from economic modeling due to savings from reduction in diabetes-related costs.
Key wordsBariatric surgery type 2 diabetes mellitus morbid obesity literature review treatment outcome weight loss
- The comparative effects of bariatric surgery on weight and type 2 diabetes
Volume 17, Issue 9 , pp 1248-1256
- Cover Date
- Print ISSN
- Online ISSN
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- Bariatric surgery
- type 2 diabetes mellitus
- morbid obesity
- literature review
- treatment outcome
- weight loss
- Industry Sectors
- Author Affiliations
- 1. LEGOS, University of Paris Dauphine, Place du Marechal de Lattre e Tassigny, 75775, PARIS cedex 16, France
- 2. Clinical Center for Minimally Invasive and Bariatric Surgery — ISCARE, and 1st Medical Faculty, Charles University Prague, Prague, Czech Republic
- 3. Department of Endocrinology and Metabolic Diseases, Pisa University Hospital, Pisa, Italy
- 4. Wellcome Trust Clinical Research Facility, Addenbrooke’s Hospital, Cambridge, UK