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Neural correlates of correct and failed response inhibition in heavy versus light social drinkers: an fMRI study during a go/no-go task by healthy participants

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An Erratum to this article was published on 06 December 2016

This article has been updated

Abstract

The ability to suppress responses that are inappropriate, as well as the mechanisms monitoring the accuracy of actions in order to compensate for errors, is central to human behavior. Neural alterations that prevent stopping an inaccurate response, combined with a decreased ability of error monitoring, are considered to be prominent features of alcohol abuse. Moreover, (i) alterations of these processes have been reported in heavy social drinkers (i.e. young healthy individuals who do not yet exhibit a state of alcohol dependence); and (ii) through longitudinal studies, these alterations have been shown to underlie subsequent disinhibition that may lead to future alcohol use disorders. In the present functional magnetic resonance imaging study, using a contextual Go/No-Go task, we investigated whether different neural networks subtended correct inhibitions and monitoring mechanisms of failed inhibitory trials in light versus heavy social drinkers. We show that, although successful inhibition did not lead to significant changes, neural networks involved in error monitoring are different in light versus heavy drinkers. Thus, while light drinkers exhibited activations in their right inferior frontal, right middle cingulate and left superior temporal areas; heavy drinkers exhibited activations in their right cerebellum, left caudate nucleus, left superior occipital region, and left amygdala. These data are functionally interpreted as reflecting a “visually-driven emotional strategy” vs. an “executive-based” neural response to errors in heavy and light drinkers, respectively. Such a difference is interpreted as a key-factor that may subtend the transition from a controlled social heavy consumption to a state of clinical alcohol dependence.

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  • 06 December 2016

    An erratum to this article has been published.

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Acknowledgments

Salvatore Campanella is Research Associate at the Fund of Scientific Research (FRS-FNRS, Belgium). Mathieu Bourguignon benefits of a research grant from the FRIA (FRS-FNRS, Belgium). Xavier De Tiège is “Postdoctorate Clinical Master Specialist” at the Fund of Scientific Research (FRS-FNRS, Belgium).

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Authors and Affiliations

  1. Laboratoire de Psychologie Médicale et d’Addiction, ULB Neuroscience Institute (UNI), Université Libre de Bruxelles (ULB), Place Vangehuchten, B-1020, Brussels, Belgium

    Salvatore Campanella, Elisa Schroder & Paul Verbanck

  2. Department of Radiology, ULB-Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium

    Julie Absil, Thierry Metens & Mustapha Nouali

  3. Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain

    Carina Carbia Sinde

  4. Neuropsychology and Functional Neuroimaging Research Unit (UR2NF) at Centre de Recherches en Cognition et Neurosciences (CRCN), ULB Neuroscience Institute (UNI), Université Libre de Bruxelles (ULB), Brussels, Belgium

    Philippe Peigneux

  5. Laboratoire de Cartographie fonctionnelle du Cerveau, ULB Neuroscience Institute (UNI), Université Libre de Bruxelles (ULB), Brussels, Belgium

    Mathieu Bourguignon, Serge Goldman & Xavier De Tiège

  6. BCBL, Basque Center on Cognition, Brain and Language, San Sebastian, Spain

    Mathieu Bourguignon

  7. Laboratory of Neurophysiology and Movement Biomechanics, ULB Neuroscience Institute (UNI), Université Libre de Bruxelles (ULB), Brussels, Belgium

    Mathieu Petieau & Guy Cheron

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  1. Salvatore Campanella
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  2. Julie Absil
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  3. Carina Carbia Sinde
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  5. Philippe Peigneux
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  6. Mathieu Bourguignon
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  9. Mustapha Nouali
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  10. Serge Goldman
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  11. Guy Cheron
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  12. Paul Verbanck
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  13. Xavier De Tiège
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Corresponding author

Correspondence to Salvatore Campanella.

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Disclosure

This study was financially supported by the Fund of Scientific Research (Research Grant J.0009.13, FRS-FNRS, Belgium).

Conflict of interest

The authors have no competing financial interest, potential conflict of interest, or financial relationship with commercial entities to report.

Funding

They are funded by the Belgian Fund for Scientific Research (F.N.R.S., Belgium), but this fund did not exert any editorial direction or censorship on any part of this article.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

The original version of this article was revised: There are errors in the name of two authors. Xavier Detiège should be changed to Xavier De Tiège, where De Tiège is the last name, and Carbia Sinde should be captured as the last name for Carina Carbia Sinde.

An erratum to this article is available at https://doi.org/10.1007/s11682-016-9664-9.

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Campanella, S., Absil, J., Carbia Sinde, C. et al. Neural correlates of correct and failed response inhibition in heavy versus light social drinkers: an fMRI study during a go/no-go task by healthy participants. Brain Imaging and Behavior 11, 1796–1811 (2017). https://doi.org/10.1007/s11682-016-9654-y

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