Skip to main content

Advertisement

SpringerLink
Log in

Brain structure and function in patients with ovarian cancer treated with first-line chemotherapy: a pilot study

  • Original Research
  • Published:
Brain Imaging and Behavior Aims and scope Submit manuscript

Abstract

Women with ovarian cancer often undergo chemotherapy involving multiple agents. However, little is known about treatment-related central neurotoxicity in this population. The goal of this cross-sectional study was to assess brain structure and function and neurocognitive abilities in patients with ovarian cancer following first-line chemotherapy. Eighteen patients with ovarian, peritoneal and fallopian tube cancer and eighteen healthy controls matched for gender, age and education participated in the study. The patients were evaluated 1–4 months following completion of first-line taxane/platinum chemotherapy. All participants underwent structural and functional magnetic resonance imaging (MRI), and completed neuropsychological tests of attention, memory and executive functions. Neuroimaging assessments included voxel-based morphometry (VBM) for measuring gray matter (GM) volume, and functional MRI (fMRI) during the N-back working memory task. The results of VBM showed that patients had significantly reduced GM volume compared to healthy controls in the right middle/superior frontal gyrus, and in the left supramarginal gyrus and left inferior parietal lobule. fMRI results indicated significantly decreased activation in patients relative to healthy controls in the left middle frontal gyrus and left inferior parietal lobule during the N-back task (1/2/3-back >0-back). There were no statistically significant differences between the two groups on the neuropsychological tests. This is the first study showing structural and functional alterations involving frontal and parietal regions in patients with ovarian cancer treated with first-line chemotherapy. These findings are congruent with studies involving women with breast cancer, and provide additional supporting evidence for central neurotoxicity associated with taxane/platinum chemotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Ahles, T. A., & Saykin, A. J. (2007). Candidate mechanisms for chemotherapy-induced cognitive changes. Nature Reviews Cancer, 7(3), 192–201.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ahles, T. A., Saykin, A. J., Furstenberg, C. T., Cole, B., Mott, L. A., Skalla, K., et al. (2002). Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. Journal of Clinical Oncology, 20(2), 485–493.

    Article  CAS  PubMed  Google Scholar 

  • Ahles, T. A., Saykin, A. J., Noll, W. W., Furstenberg, C. T., Guerin, S., Cole, B., et al. (2003). The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy. Psychooncology, 12(6), 612–619.

    Article  PubMed  Google Scholar 

  • Ahles, T. A., Saykin, A. J., McDonald, B. C., Li, Y., Furstenberg, C. T., Hanscom, B. S., et al. (2010). Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. Journal of Clinical Oncology, 28(29), 4434–4440.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ahles, T. A., Root, J. C., & Ryan, E. L. (2012). Cancer- and cancer treatment-associated cognitive change: an update on the state of the science. Journal of Clinical Oncology, 30(30), 3675–3686.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barona, A., Reynolds, C. R., & Chastain, R. (1984). A demographically based index of premorbid intelligence for the WAIS-R. Journal of Consulting and Clinical Psychology, 52(5), 885–887.

    Article  Google Scholar 

  • Basen-Engquist, K., Bodurka-Bevers, D., Fitzgerald, M. A., Webster, K., Cella, D., Hu, S., et al. (2001). Reliability and validity of the functional assessment of cancer therapy-ovarian. Journal of Clinical Oncology, 19(6), 1809–1817.

    Article  CAS  PubMed  Google Scholar 

  • Benton, L., Hamsher, K., & Sivan, A. (1983). Controlled oral word association test. Multilingual aphasia examination (3rd ed.). San Antonio: Psychological Corporation.

    Google Scholar 

  • Blair, J. R., & Spreen, O. (1989). Predicting premorbid IQ: a revision of the national adult reading test. The Clinical Neuropsychologist, 3(2), 129–136.

    Article  Google Scholar 

  • Braga, R. M., Sharp, D. J., Leeson, C., Wise, R. J., & Leech, R. (2013). Echoes of the brain within default mode, association, and heteromodal cortices. Journal of Neuroscience, 33(35), 14031–14039.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brewer, J. R., Morrison, G., Dolan, M. E., & Fleming, G. F. (2016). Chemotherapy-induced peripheral neuropathy: Current status and progress. Gynecologic Oncology, 140(1), 176–183.

    Article  CAS  PubMed  Google Scholar 

  • Brezden, C. B., Phillips, K. A., Abdolell, M., Bunston, T., & Tannock, I. F. (2000). Cognitive function in breast cancer patients receiving adjuvant chemotherapy. Journal of Clinical Oncology, 18(14), 2695–2701.

    Article  CAS  PubMed  Google Scholar 

  • Cella, D. (1997). Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System. Evanston: Research and Education Core, Evanston Northwestern Healthcare.

    Google Scholar 

  • Collins, B., Mackenzie, J., Tasca, G. A., Scherling, C., & Smith, A. (2013). Persistent Cognitive Changes in Breast Cancer Patients 1 Year Following Completion of Chemotherapy. Journal of the International Neuropsychological Society, 20(04), 370–379.

    Article  PubMed  Google Scholar 

  • Conroy, S. K., McDonald, B. C., Smith, D. J., Moser, L. R., West, J. D., Kamendulis, L. M., et al. (2013). Alterations in brain structure and function in breast cancer survivors: effect of post-chemotherapy interval and relation to oxidative DNA damage. Breast Cancer Research and Treatment, 137(2), 493–502.

    Article  CAS  PubMed  Google Scholar 

  • Correa, D. D., & Ahles, T. A. (2008). Neurocognitive changes in cancer survivors. Cancer Journal, 14(6), 396–400.

    Article  Google Scholar 

  • Correa, D. D., DeAngelis, L. M., Shi, W., Thaler, H. T., Lin, M., & Abrey, L. E. (2007). Cognitive functions in low-grade gliomas: disease and treatment effects. Journal of Neurooncology, 81(2), 175–184.

    Article  Google Scholar 

  • Correa, D. D., Zhou, Q., Thaler, H. T., Maziarz, M., Hurley, K., & Hensley, M. L. (2010). Cognitive functions in long-term survivors of ovarian cancer. Gynecologic Oncology, 119(2), 366–369.

    Article  PubMed  Google Scholar 

  • Correa, D. D., Satagopan, J., Baser, R. E., Cheung, K., Richards, E., Lin, M., et al. (2014). APOE polymorphisms and cognitive functions in patients with brain tumors. Neurology, 83(4), 320–327.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Correa, D. D., Satagopan, J., Cheung, K., Arora, A. K., Kryza-Lacombe, M., Xu, Y., et al. (2016). COMT, BDNF, and DTNBP1 polymorphisms and cognitive functions in patients with brain tumors. Neuro-Oncology, 2016. doi:10.1093/neuonc/now057.

  • de Ruiter, M. B., Reneman, L., Boogerd, W., Veltman, D. J., van Dam, F. S., Nederveen, A. J., et al. (2011). Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer. Human Brain Mapping, 32(8), 1206–1219.

    Article  PubMed  Google Scholar 

  • de Ruiter, M. B., Reneman, L., Boogerd, W., Veltman, D. J., Caan, M., Douaud, G., et al. (2012). Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: converging results from multimodal magnetic resonance imaging. Human Brain Mapping, 33(12), 2971–2983.

    Article  PubMed  Google Scholar 

  • Delis, D., Kramer, J., Kaplan, E., & Ober, B. (2000). CVLT-II. New York: The Psychological Corporation.

    Google Scholar 

  • Deprez, S., Billiet, T., Sunaert, S., & Leemans, A. (2013). Diffusion tensor MRI of chemotherapy-induced cognitive impairment in non-CNS cancer patients: a review. Brain Imaging and Behavior, 7(4), 409–435.

    Article  PubMed  Google Scholar 

  • Deprez, S., Vandenbulcke, M., Peeters, R., Emsell, L., Smeets, A., Christiaens, M. R., et al. (2014). Longitudinal assessment of chemotherapy-induced alterations in brain activation during multitasking and its relation with cognitive complaints. Journal of Clinical Oncology, 32(19), 2031–2038.

    Article  PubMed  Google Scholar 

  • Dietrich, J., Han, R., Yang, Y., Mayer-Proschel, M., & Noble, M. (2006). CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. Journal of Biology, 5(7), 1–23.

    Article  Google Scholar 

  • Donovan, K. A., Small, B. J., Andrykowski, M. A., Schmitt, F. A., Munster, P., & Jacobsen, P. B. (2005). Cognitive functioning after adjuvant chemotherapy and/or radiotherapy for early-stage breast carcinoma. Cancer, 104(11), 2499–2507.

    Article  PubMed  PubMed Central  Google Scholar 

  • Eberling, J. L., Wu, C., Tong-Turnbeaugh, R., & Jagust, W. J. (2004). Estrogen- and tamoxifen-associated effects on brain structure and function. NeuroImage, 21(1), 364–371.

    Article  PubMed  Google Scholar 

  • Ferguson, R. J., McDonald, B. C., Saykin, A. J., & Ahles, T. A. (2007). Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy. Journal of Clinical Oncology, 25(25), 3866–3870.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hayasaka, S., & Nichols, T. E. (2004). Combining voxel intensity and cluster extent with permutation test framework. NeuroImage, 23(1), 54–63.

    Article  PubMed  Google Scholar 

  • Heaton, R. K., Walden Miller, S., Taylor, M. J., & Grant, I. (2004). Revised comprehensive norms for an expanded Halstead-Reitan battery: Demographically adjusted neuropsychological norms for african american and caucasian adults. Florida: Psychological Assessment Resources Inc..

    Google Scholar 

  • Hensley, M. L., Correa, D. D., Thaler, H., Wilton, A., Venkatraman, E., Sabbatini, P., et al. (2006). Phase I/II study of weekly paclitaxel plus carboplatin and gemcitabine as first-line treatment of advanced-stage ovarian cancer: pathologic complete response and longitudinal assessment of impact on cognitive functioning. Gynecologic Oncology, 102(2), 270–277.

    Article  CAS  PubMed  Google Scholar 

  • Hess, L. M., Chambers, S. K., Hatch, K., Hallum, A., Janicek, M. F., Buscema, J., et al. (2010). Pilot study of the prospective identification of changes in cognitive function during chemotherapy treatment for advanced ovarian cancer. Journal of Supportive Oncology, 8(6), 252–258.

    Article  PubMed  Google Scholar 

  • Hess, L. M., Huang, H. Q., Hanlon, A. L., Robinson, W. R., Johnson, R., Chambers, S. K., et al. (2015). Cognitive function during and six months following chemotherapy for front-line treatment of ovarian, primary peritoneal or fallopian tube cancer: an NRG oncology/gynecologic oncology group study. Gynecologic Oncology, 139(3), 541–545.

    Article  PubMed  PubMed Central  Google Scholar 

  • Inagaki, M., Yoshikawa, E., Matsuoka, Y., Sugawara, Y., Nakano, T., Akechi, T., et al. (2007). Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy. Cancer, 109(1), 146–156.

    Article  PubMed  Google Scholar 

  • Kayl, A. E., & Meyers, C. A. (2006). Side-effects of chemotherapy and quality of life in ovarian and breast cancer patients. Current Opinion in Obstetrics & Gynecology, 18(1), 24–28.

    Article  Google Scholar 

  • Kesler, S. R., Bennett, F. C., Mahaffey, M. L., & Spiegel, D. (2009). Regional brain activation during verbal declarative memory in metastatic breast cancer. Clinical Cancer Research, 15(21), 6665–6673.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kesler, S. R., Kent, J. S., & O'Hara, R. (2011). Prefrontal cortex and executive function impairments in primary breast cancer. Archives of Neurology, 68(11), 1447–1453.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kluetsch, R. C., Schmahl, C., Niedtfeld, I., Densmore, M., Calhoun, V. D., Daniels, J., et al. (2012). Alterations in default mode network connectivity during pain processing in borderline personality disorder. Archives of General Psychiatry, 69(10), 993–1002.

    Article  PubMed  PubMed Central  Google Scholar 

  • Koppelmans, V., de Ruiter, M. B., van der Lijn, F., Boogerd, W., Seynaeve, C., van der Lugt, A., et al. (2012). Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy. Breast Cancer Research and Treatment, 132(3), 1099–1106.

    Article  CAS  PubMed  Google Scholar 

  • Leung, A. W., & Alain, C. (2011). Working memory load modulates the auditory "What" and "Where" neural networks. NeuroImage, 55(3), 1260–1269.

    Article  PubMed  Google Scholar 

  • Lewinsohn, P. M., Seeley, J. R., Roberts, R. E., & Allen, N. B. (1997). Center for Epidemiologic Studies Depression Scale (CES-D) as a screening instrument for depression among community-residing older adults. Psychology and Aging, 12(2), 277–287.

    Article  CAS  PubMed  Google Scholar 

  • Lopez Zunini, R. A., Scherling, C., Wallis, N., Collins, B., MacKenzie, J., Bielajew, C., et al. (2013). Differences in verbal memory retrieval in breast cancer chemotherapy patients compared to healthy controls: a prospective fMRI study. Brain Imaging and Behavior, 7(4), 460–477.

    Article  PubMed  Google Scholar 

  • Manohar, S., Jamesdaniel, S., & Salvi, R. (2014). Cisplatin inhibits hippocampal cell proliferation and alters the expression of apoptotic genes. Neurotoxicity Research, 25(4), 369–380.

    Article  CAS  PubMed  Google Scholar 

  • Marshuetz, C., Smith, E. E., Jonides, J., DeGutis, J., & Chenevert, T. L. (2000). Order information in working memory: fMRI evidence for parietal and prefrontal mechanisms. Journal of Cognitive Neuroscience, 12(Suppl 2), 130–144.

    Article  PubMed  Google Scholar 

  • Mayerhofer, K., Bodner-Adler, B., Bodner, K., Saletu, B., Schindl, M., Kaider, A., et al. (2000). A paclitaxel-containing chemotherapy does not cause central nervous adverse effects: a prospective study in patients with ovarian cancer. Anticancer Research, 20(5c), 4051–4055.

    CAS  PubMed  Google Scholar 

  • McAllister, T. W., Sparling, M. B., Flashman, L. A., Guerin, S. J., Mamourian, A. C., & Saykin, A. J. (2001). Differential working memory load effects after mild traumatic brain injury. NeuroImage, 14(5), 1004–1012.

    Article  CAS  PubMed  Google Scholar 

  • McDonald, B. C., & Saykin, A. J. (2013). Alterations in brain structure related to breast cancer and its treatment: chemotherapy and other considerations. Brain Imaging and Behavior, 7(4), 374–387.

    Article  PubMed  Google Scholar 

  • McDonald, B. C., Conroy, S. K., Ahles, T. A., West, J. D., & Saykin, A. J. (2010). Gray matter reduction associated with systemic chemotherapy for breast cancer: a prospective MRI study. Breast Cancer Research and Treatment, 123(3), 819–828.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McDonald, B. C., Conroy, S. K., Ahles, T. A., West, J. D., & Saykin, A. J. (2012). Alterations in brain activation during working memory processing associated with breast cancer and treatment: a prospective functional magnetic resonance imaging study. Journal of Clinical Oncology, 30(20), 2500–2508.

    Article  PubMed  PubMed Central  Google Scholar 

  • McDonald, B. C., Conroy, S. K., Smith, D. J., West, J. D., & Saykin, A. J. (2013). Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: a replication and extension study. Brain, Behavior, and Immunity, 30(Suppl), S117–S125.

    Article  PubMed  Google Scholar 

  • McGuire 3rd, W. P., & Markman, M. (2003). Primary ovarian cancer chemotherapy: current standards of care. British Journal of Cancer, 89(Suppl 3), S3–S8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Morrison, J., Swanton, A., Collins, S., & Kehoe, S. (2007). Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer. Cochrane Database of Systematic Reviews, 4, CD005343.

    Google Scholar 

  • Nenadic, I., Smesny, S., Schlosser, R. G., Sauer, H., & Gaser, C. (2010). Auditory hallucinations and brain structure in schizophrenia: voxel-based morphometric study. British Journal of Psychiatry, 196(5), 412–413.

    Article  PubMed  Google Scholar 

  • Niedtfeld, I., Schulze, L., Krause-Utz, A., Demirakca, T., Bohus, M., & Schmahl, C. (2013). Voxel-based morphometry in women with borderline personality disorder with and without comorbid posttraumatic stress disorder. PloS One, 8(6), e65824.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nudelman, K. N., McDonald, B. C., Wang, Y., Smith, D. J., West, J. D., O’Neill, D. P., et al. (2016). Cerebral perfusion and gray matter changes associated with chemotherapy-induced peripheral neuropathy. Journal of Clinical Oncology, 34(7), 677–683.

    Article  CAS  PubMed  Google Scholar 

  • Owen, A. M., McMillan, K. M., Laird, A. R., & Bullmore, E. (2005). N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Human Brain Mapping, 25(1), 46–59.

    Article  PubMed  Google Scholar 

  • Ozols, R. F. (2002). Update on the management of ovarian cancer. Cancer Journal, 8 Suppl 1, S22–30.

  • Petersen, S. E., Fox, P. T., Posner, M. I., Mintun, M., & Raichle, M. E. (1988). Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature, 331(6157), 585–589.

    Article  CAS  PubMed  Google Scholar 

  • Philip, N. S., Sweet, L. H., Tyrka, A. R., Carpenter, S. L., Albright, S. E., Price, L. H., et al. (2016). Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task. Brain Imaging and Behavior, 10(1), 124–135.

    Article  PubMed  PubMed Central  Google Scholar 

  • Posner, M. I., Petersen, S. E., Fox, P. T., & Raichle, M. E. (1988). Localization of cognitive operations in the human brain. Science, 240(4859), 1627–1631.

    Article  CAS  PubMed  Google Scholar 

  • Radloff, L. S. (1977). The CES-D scale: a self-report depression scale for research in the general population. Applied Psychological Measurement, 1(3), 385–401.

    Article  Google Scholar 

  • Ragland, J. D., Turetsky, B. I., Gur, R. C., Gunning-Dixon, F., Turner, T., Schroeder, L., et al. (2002). Working memory for complex figures: an fMRI comparison of letter and fractal n-back tasks. Neuropsychology, 16(3), 370–379.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rzeski, W., Pruskil, S., Macke, A., Felderhoff-Mueser, U., Reiher, A. K., Hoerster, F., et al. (2004). Anticancer agents are potent neurotoxins in vitro and in vivo. Annals of Neurology, 56(3), 351–360.

    Article  CAS  PubMed  Google Scholar 

  • Scherling, C., Collins, B., Mackenzie, J., Bielajew, C., & Smith, A. (2011). Pre-chemotherapy differences in visuospatial working memory in breast cancer patients compared to controls: an FMRI study. Frontiers in Human Neuroscience, 5, 122.

    Article  PubMed  PubMed Central  Google Scholar 

  • Scherling, C., Collins, B., Mackenzie, J., Bielajew, C., & Smith, A. (2012). Prechemotherapy differences in response inhibition in breast cancer patients compared to controls: a functional magnetic resonance imaging study. Journal of Clinical and Experimental Neuropsychology, 34(5), 543–560.

    Article  PubMed  Google Scholar 

  • Scherwath, A., Mehnert, A., Schleimer, B., Schirmer, L., Fehlauer, F., Kreienberg, R., et al. (2006). Neuropsychological function in high-risk breast cancer survivors after stem-cell supported high-dose therapy versus standard-dose chemotherapy: evaluation of long-term treatment effects. Annals of Oncology, 17(3), 415–423.

    Article  CAS  PubMed  Google Scholar 

  • Schilder, C. M., & Schagen, S. B. (2007). Effects of hormonal therapy on cognitive functioning in breast cancer patients: a review of the literature. Minerva Ginecologica, 59(4), 387–401.

    CAS  PubMed  Google Scholar 

  • Schilder, C. M., Seynaeve, C., Beex, L. V., Boogerd, W., Linn, S. C., Gundy, C. M., et al. (2010). Effects of tamoxifen and exemestane on cognitive functioning of postmenopausal patients with breast cancer: results from the neuropsychological side study of the tamoxifen and exemestane adjuvant multinational trial. Journal of Clinical Oncology, 28(8), 1294–1300.

    Article  CAS  PubMed  Google Scholar 

  • Schretlen, D., Bobholz, J. H., & Brandt, J. (1996). Development and psychometric properties of the brief test of attention. The Clinical Neuropsychologist, 10(1), 80–89.

    Article  Google Scholar 

  • Shuster, L. T., Gostout, B. S., Grossardt, B. R., & Rocca, W. A. (2008). Prophylactic oophorectomy in premenopausal women and long-term health. Menopause International, 14(3), 111–116.

    PubMed  PubMed Central  Google Scholar 

  • Siegel, R. L., Miller, K. D., & Jemal, A. (2015). Cancer statistics, 2015. CA: A Cancer Journal for Clinicians, 65(1), 5–29.

    Google Scholar 

  • Stouten-Kemperman, M. M., de Ruiter, M. B., Boogerd, W., Veltman, D. J., & Reneman, L. (2015). Very late treatment-related alterations in brain function of breast cancer survivors. Journal of the International Neuropsychological Society, 21(1), 50–61.

    Article  PubMed  Google Scholar 

  • Tuxen, M. K., & Hansen, S. W. (1994). Neurotoxicity secondary to antineoplastic drugs. Cancer Treatment Reviews, 20(2), 191–214.

    Article  CAS  PubMed  Google Scholar 

  • Vardy, J., Wefel, J. S., Ahles, T., Tannock, I. F., & Schagen, S. B. (2008). Cancer and cancer-therapy related cognitive dysfunction: an international perspective from the Venice cognitive workshop. Annals of Oncology, 19(4), 623–629.

    Article  CAS  PubMed  Google Scholar 

  • Vichaya, E. G., Chiu, G. S., Krukowski, K., Lacourt, T. E., Kavelaars, A., Dantzer, R., et al. (2015). Mechanisms of chemotherapy-induced behavioral toxicities. Frontiers in Neuroscience, 9, 131.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wechsler, D. (2009). Wechsler memory scale-(WMS-IV). New York: The Psychological Corporation.

    Google Scholar 

  • Wefel, J. S., Kayl, A. E., & Meyers, C. A. (2004a). Neuropsychological dysfunction associated with cancer and cancer therapies: a conceptual review of an emerging target. British Journal of Cancer, 90(9), 1691–1696.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wefel, J. S., Lenzi, R., Theriault, R. L., Davis, R. N., & Meyers, C. A. (2004b). The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial. Cancer, 100(11), 2292–2299.

    Article  CAS  PubMed  Google Scholar 

  • Wefel, J. S., Saleeba, A. K., Buzdar, A. U., & Meyers, C. A. (2010). Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer. Cancer, 116(14), 3348–3356.

    Article  PubMed  Google Scholar 

  • Yellen, S. B., Cella, D. F., Webster, K., Blendowski, C., & Kaplan, E. (1997). Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. Journal of Pain and Symptom Management, 13(2), 63–74.

    Article  CAS  PubMed  Google Scholar 

  • Zhou, W., Kavelaars, A., & Heijnen, C. J. (2016). Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice. PloS One, 11(3), e0151890.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Funding

This study was funded by the Leon Levy Foundation.

Author information

Authors and Affiliations

  1. Departments of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA

    D. D. Correa & M. Kryza-Lacombe

  2. Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    J. C. Root

  3. Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    M. Mehta

  4. Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    S. Karimi

  5. Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    M. L. Hensley

  6. New York, NY, USA

    N. Relkin

Authors
  1. D. D. Correa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. C. Root
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Kryza-Lacombe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Mehta
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Karimi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. L. Hensley
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. N. Relkin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. D. Correa.

Ethics declarations

Conflict of interest

Dr. Correa serves on the Editorial Board of Neuro-Oncology Practice and on the Neurotoxicity Advisory Board for Juno Therapeutics.

Dr. Root reports no conflicts of interest.

Ms. Kryza-Lacombe reports no conflicts of interest.

Ms. Mehta reports no conflicts of interest.

Dr. Karimi reports no conflicts of interest.

Dr. Hensley reports no conflicts of interest.

Dr. Relkin has received remuneration from Eisai, HerbalScience Group, Anavex and Forest for consulting services. He has served as an investigator in clinical trials sponsored by the NIH, DOD, Baxter, Merck, Lilly and Eisai. He is a past recipient of grant support from the Leon Levy Foundation.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Correa, D.D., Root, J.C., Kryza-Lacombe, M. et al. Brain structure and function in patients with ovarian cancer treated with first-line chemotherapy: a pilot study. Brain Imaging and Behavior 11, 1652–1663 (2017). https://doi.org/10.1007/s11682-016-9608-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11682-016-9608-4

Keywords

Search

Navigation