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Cognitive dysfunction and symptom burden in women treated for breast cancer: a prospective behavioral and fMRI analysis

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Abstract

Neural dysfunction and cognitive complaints are associated with chemotherapy for breast cancer although trajectory and contributory factors remain unclear. We prospectively examined neurocognition using fMRI and self-reported cognitive, physical and psychological symptoms in women treated with adjuvant chemotherapy over one year. Patients treated with (n = 28) or without (n = 34) chemotherapy for localized breast cancer and healthy controls (n = 30) performed a Verbal Working Memory Task (VWMT) during fMRI and provided self-reports at baseline (pre-adjuvant treatment), five- (M5) and 12-months (M12). Repeated measures ANOVA and multivariable regression determined change over time and possible predictors (e.g., hemoglobin, physical symptoms, worry) of VWMT performance, fMRI activity in the frontoparietal executive network, and cognitive complaints at M12. Trajectories of change in VWMT performance for chemotherapy and healthy control groups differed significantly with the chemotherapy group performing worse at M12. Chemotherapy patients had persistently higher spatial variance (neural inefficiency) in executive network fMRI-activation than both other groups from baseline to M12. Cognitive complaints were similar among groups over time. At M12, VWMT performance and executive network spatial variance were each independently predicted by chemotherapy treatment and their respective baseline values, while cognitive complaints were predicted by baseline level, physical symptoms and worry. Executive network inefficiency and neurocognitive performance deficits pre-adjuvant treatment predict cognitive dysfunction one-year post-baseline, particularly in chemotherapy-treated patients. Persistent cognitive complaints are linked with physical symptom severity and worry regardless of treatment. Pre-chemotherapy interventions should target both neurocognitive deficits and symptom burden to improve cognitive outcomes for breast cancer survivors.

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Acknowledgments

This work was supported by the National Institutes of Health R01 NR01039 (BC).

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Authors and Affiliations

  1. College of Nursing Chungnam National University, 266 Munhwa-ro Jung-gu, Daejeon, 35015, South Korea

    Mi Sook Jung

  2. University of Michigan, 500 S State St, Ann Arbor, MI, 48109, USA

    Min Zhang, Scott Peltier, Daniel F. Hayes, Barbara Therrien, Patricia A. Reuter-Lorenz & Bernadine Cimprich

  3. University of Washington, Seattle, WA, USA

    Mary K. Askren

  4. University of Chicago, 5801 S Ellis Ave, Chicago, IL, 60637, USA

    Marc G. Berman

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  1. Mi Sook Jung
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  2. Min Zhang
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Correspondence to Mi Sook Jung.

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Mi Sook Jung, Min Zhang, Mary K. Askren, Marc G. Berman, Scott Peltier, Daniel F. Hayes, Barbara Therrien, Patricia A. Reuter-Lorenz, and Bernadine Cimprich declare that they have no conflicts of interest.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all participants included in the study.

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Jung, M.S., Zhang, M., Askren, M.K. et al. Cognitive dysfunction and symptom burden in women treated for breast cancer: a prospective behavioral and fMRI analysis. Brain Imaging and Behavior 11, 86–97 (2017). https://doi.org/10.1007/s11682-016-9507-8

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