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CapMan: independent investigation of capacity and manipulation with a new working memory paradigm

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Abstract

In a new working memory paradigm, CapMan, we independently investigated brain activity associated with capacity and manipulation of information. The investigation of Capacity, resulted in activation of the fronto-parietal network of regions that overlapped with areas usually found to be active in working memory tasks. The investigation of Manipulation revealed a more dorsal network of areas that also overlapped with areas usually found to be active in working memory tasks, but that did not overlap with the areas associated with Capacity. The CapMan paradigm thus appears to be able to separate the processes associated with capacity and manipulation increases and promises to be a valuable addition to the tools available for the study of working memory.

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References

  • Barbey, A. K., Koenigs, M., & Grafman, J. (2013). Dorsolateral prefrontal contributions to human working memory. Cortex, 49, 1195–1205.

    Article  PubMed Central  PubMed  Google Scholar 

  • Callicott, J. H., Mattay, V. S., Bertolino, A., Finn, K., Coppola, R., Frank, J. A., Goldberg, T. E., & Weinberger, D. R. (1999). Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cerebral Cortex, 9, 20–26.

    Article  CAS  PubMed  Google Scholar 

  • Champod, A. S., & Petrides, M. (2007). Dissociable roles of the posterior parietal and the prefrontal cortex in manipulation and monitoring processes. Proceedings of the National Academy of Sciences of the United States of America, 104, 14837–14842.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Champod, A. S., & Petrides, M. (2010). Dissociation within the frontoparietal network in verbal working memory: a parametric functional magnetic resonance imaging study. The Journal of neuroscience: the official journal of the Society for Neuroscience, 30, 3849–3856.

    Article  CAS  Google Scholar 

  • Christodoulou, C., DeLuca, J., Ricker, J. H., Madigan, N. K., Bly, B. M., Lange, G., Kalnin, A. J., Liu, W. C., Steffener, J., Diamond, B. J., & Ni, A. C. (2001). Functional magnetic resonance imaging of working memory impairment after traumatic brain injury. Journal of Neurology, Neurosurgery and Psychiatry, 71, 161–168.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Cohen, J. D., Perlstein, W. M., Braver, T. S., Nystrom, L. E., Noll, D. C., Jonides, J., & Smith, E. E. (1997). Temporal dynamics of brain activation during a working memory task. Nature, 386, 604–608.

    Article  CAS  PubMed  Google Scholar 

  • Cools, R. & D’Esposito, M. (2011). Inverted-U shaped dopamine actions on human working memory and cognitive control. Biological Psychiatry, 69(12), e113 e125.

  • Cox, R. W. (1996). AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Computers and biomedical research, an international journal, 29, 162–173.

    Article  CAS  PubMed  Google Scholar 

  • D’Esposito, M., Postle, B. R., & Rypma, R. (2000). Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies. Experimental Brain Research, 133, 3–11.

    Article  PubMed  Google Scholar 

  • Jansma, J. M., Ramsey, N. F., Coppola, R., & Kahn, R. S. (2000). Specific versus nonspecific brain activity in a parametric N-back task. NeuroImage, 12, 688–697.

    Article  CAS  PubMed  Google Scholar 

  • Jansma, J. M., Ramsey, N. F., de Zwart, J. A., van Gelderen, P., & Duyn, J. H. (2007). fMRI study of effort and information processing in a working memory task. Human brain mapping, 28, 431–440.

    Article  CAS  PubMed  Google Scholar 

  • Kasahara, M., Menon, D. K., Salmond, C. H., Outtrim, J. G., Tavares, J. V. T., Carpenter, T. A., & Stamatakis, E. a. (2011). Traumatic brain injury alters the functional brain network mediating working memory. Brain injury. [BI], 25(12), 1170-1187.

    Google Scholar 

  • Koch, K., Wagner, G., von Consbruch, K., Nenadic, I., Schultz, C., Ehle, C., Reichenbach, J., Sauer, H., & Schlosser, R. (2006). Temporal changes in neural activation during practice of information retrieval from short-term memory: an fMRI study. Brain research, 1107, 140–150.

    Article  CAS  PubMed  Google Scholar 

  • McDonald, B. C., Saykin, A. J., & McAllister, T. W. (2012). Functional MRI of mild traumatic brain injury (mTBI): progress and perspectives from the first decade of studies. Brain imaging and behavior, 6, 193–207.

    Article  PubMed Central  PubMed  Google Scholar 

  • Muller, N. G., & Knight, R. T. (2006). The functional neuroanatomy of working memory: contributions of human brain lesion studies. Neuroscience, 139, 51–58.

    Article  CAS  PubMed  Google Scholar 

  • Narayanan, N. S., Prabhakaran, V., Bunge, S. A., Christoff, K., Fine, E. M., & Gabrieli, J. D., (2005). The role of the prefrontal cortex in the maintenance of verbal working memory: an event-related FMRI analysis. Neuropsychology 19, 223-232.

  • O’Doherty, J. (2011). Contributions of the ventromedial prefrontal cortex to goal-directed action selection. In Schoenbaum, G., Gottfried, J.A., Murray, E.A., Ramus, S.J. (Eds). Blackwell Science Publ, Oxford, pp. 118–129.

  • Owen, A. M., Herrod, N. J., Menon, D. K., Clark, J. C., Downey, S. P., Carpenter, T. A., Minhas, P. S., Turkheimer, F. E., Williams, E. J., Robbins, T. W., Sahakian, B. J., Petrides, M., & Pickard, J. D. (1999). Redefining the functional organization of working memory processes within human lateral prefrontal cortex. European Journal of Neuroscience, 11, 567–574.

    Article  CAS  PubMed  Google Scholar 

  • Owen, A. M., McMillan, K. M., Laird, A. R., & Bullmore, E. (2005). N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Human brain mapping, 25, 46–59.

    Article  PubMed  Google Scholar 

  • Poldrack, R. A., Mumford, J. A., & Nichols, T. E. (2011). Handbook of Functional MRI. Data Analysis New York, NY. Cambridge University Press. (p. 238).

  • Rawley, J. B., & Constantinidis, C. (2009). Neural correlates of learning and working memory in the primate posterior parietal cortex. Neurobiology of learning and memory, 91, 129–138.

    Article  PubMed Central  PubMed  Google Scholar 

  • Schneider, W., Eschman, A., & Zuccolotto, A. (2002). E-Prime user’s guide. Pittsburgh. Psychology Software Tools Inc. pp. A19 A35.

  • Veltman, D. J., Rombouts, S. A., & Dolan, R. J. (2003a). Maintenance versus manipulation in verbal working memory revisited: an fMRI study. NeuroImage, 18, 247–256.

    Article  PubMed  Google Scholar 

  • Veltman, D. J., Rombouts, S. A. R. B., & Dolan, R. J. (2003b). Maintenance versus manipulation in verbal working memory revisited: an fMRI study. NeuroImage, 18, 247–256.

    Article  PubMed  Google Scholar 

  • Wager, T. D., & Smith, E. E. (2003a). Neuroimaging studies of working memory: a meta-analysis. Cognitive, Affective, & Behavioral Neuroscience, 3, 255–274.

    Article  Google Scholar 

  • Wager, T. D., & Smith, E. E. (2003b). Neuroimaging studies of working memory: a meta-analysis. Cognitive, Affective, & Behavioral Neuroscience, 3, 255–274.

    Article  Google Scholar 

  • Wylie, G. R., Javitt, D. C., & Foxe, J. J. (2004). Don’t think of a white bear: an fMRI investigation of the effects of sequential instructional sets on cortical activity in a task-switching paradigm. Human Brain Mapping, 21, 279–297.

    Article  PubMed  Google Scholar 

  • Wylie, G. R., Javitt, D. C., & Foxe, J. J. (2006). Jumping the gun: is effective preparation contingent upon anticipatory activation in task-relevant neural circuitry? Cerebral Cortex, 16, 394–404.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgment

This project was supported by grants from the Kessler Foundation Research Center and from the National Institutes of Health (1R42NS050007-02to Dr. Randall Barbour)

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Authors and Affiliations

  1. Neuropsychology & Neuroscience Laboratory, Kessler Foundation Research Center, 300 Executive Drive, Suite 70, West Orange, NJ, 07052, USA

    Ekaterina Dobryakova, Adam Staffaroni, John DeLuca, James F. Sumowski, Nancy Chiaravalloti & Glenn R. Wylie

  2. Department of Physical Medicine and Rehabilitation, Rutgers University –New Jersey Medical School, Newark, NJ, USA

    Ekaterina Dobryakova, John DeLuca, James F. Sumowski, Nancy Chiaravalloti & Glenn R. Wylie

  3. Department of Neurology and Neurosciences, Rutgers University –New Jersey Medical School, Newark, NJ, USA

    John DeLuca

  4. Department of Veteran’s Affairs, War Related Illness & Injury Study Center, East Orange, NJ, USA

    Glenn R. Wylie

Authors
  1. Ekaterina Dobryakova
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  2. Adam Staffaroni
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  3. John DeLuca
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  4. James F. Sumowski
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  5. Nancy Chiaravalloti
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  6. Glenn R. Wylie
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Corresponding author

Correspondence to Glenn R. Wylie.

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Dobryakova, E., Staffaroni, A., DeLuca, J. et al. CapMan: independent investigation of capacity and manipulation with a new working memory paradigm. Brain Imaging and Behavior 8, 475–479 (2014). https://doi.org/10.1007/s11682-013-9282-8

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  • DOI: https://doi.org/10.1007/s11682-013-9282-8

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