Brain Imaging and Behavior

, Volume 7, Issue 4, pp 436–452

Integrating imaging findings in evaluating the post-chemotherapy brain

  • K. L. Pomykala
  • M. B. de Ruiter
  • S. Deprez
  • B. C. McDonald
  • D. H. S. Silverman
SI: Neuroimaging Studies of Cancer and Cancer Treatment

DOI: 10.1007/s11682-013-9239-y

Cite this article as:
Pomykala, K.L., de Ruiter, M.B., Deprez, S. et al. Brain Imaging and Behavior (2013) 7: 436. doi:10.1007/s11682-013-9239-y

Abstract

Cognitive complaints following cancer and cancer therapy are common. Many studies have investigated the effects of chemotherapy on the brain. However, the mechanisms for the associated cognitive impairment are not well understood. Some studies have also included brain imaging to investigate potential neurological substrates of cognitive changes. This review examines recent neuroimaging studies on cancer- and chemotherapy-related cognitive dysfunction in non-central nervous system cancers and compares findings across imaging modalities. Grey matter volume reductions and decreases in white matter integrity are seen after exposure to adjuvant chemotherapy for breast cancer, and functional studies have illuminated both hypo- and hyperactivations in many of the same regions months to years following therapy. These comparisons can assist in further characterizing the dysfunction reported by patients and contribute to a better understanding of the mechanisms involved.

Keywords

Functional magnetic resonance imagingMagnetic resonance imagingPositron emission tomographyDiffusion tensor imagingNeuroimagingChemotherapyCognitive complaints

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • K. L. Pomykala
    • 1
  • M. B. de Ruiter
    • 2
  • S. Deprez
    • 3
  • B. C. McDonald
    • 4
  • D. H. S. Silverman
    • 1
    • 5
  1. 1.Ahmanson Translational Imaging Division, Department of Molecular & Medical Pharmacology, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  2. 2.Department of Psychosocial Research and EpidemiologyNetherlands Cancer InstituteAmsterdamThe Netherlands
  3. 3.Department of RadiologyUniversity Hospital Gasthuisberg, Katholieke Universiteit LeuvenLeuvenBelgium
  4. 4.Center for Neuroimaging, Melvin and Bren Simon Cancer CenterIndiana University School of MedicineIndianapolisUSA
  5. 5.Department of Molecular and Medical PharmacologyDavid Geffen School of Medicine at UCLALos AngelesUSA