Abstract
Visual attention problems have been reported in association with prenatal alcohol exposure (PAE). With related behavioral data documented in literature, further investigation of this PAE effect would benefit from integrating functional and anatomical imaging data to ascertain its neurobiological basis. The current study investigated the possible functional and anatomical bases for the PAE-related visual sustained attention deficit. Functional magnetic resonance imaging (fMRI) data were collected while the subjects performed a sustained visual attention task. High resolution, three dimensional anatomical images were also collected for morphometric evaluation. In the alcohol-affected subjects, we observed a significant white and gray matter volume reduction in the occipital-temporal area. Meanwhile, their fMRI activations in the same region resided more superiorly than that of the controls resulting in reduced activation in the ventral occipital-temporal area. The location of this PAE functional abnormality approximately matches that of the significant structural reduction. In addition to the well documented corpus callosum abnormalities observed in PAE subjects, the present results reveal a teratogenic effect on the occipital-temporal area. Furthermore, as the occipital-temporal area plays an important role in visual attention, the current observation suggests a neurobiological underpinning for the PAE related deficit in sustained visual attention.
References
Archibald, S. L., Fennema-Notestine, C., Gamst, A., Riley, E. P., Mattson, S. N., & Jernigan, T. L. (2001). Brain dysmorphology in individuals with severe prenatal alcohol exposure. Developmental Medicine & Child Neurology, 43, 148–154.
Ashburner, J., & Friston, K. J. (1999). Nonlinear spatial normalization using basis functions. Human Brain Mapping, 7, 254–266.
Ashburner, J., & Friston, K. J. (2000). Voxel-based morphometry—The methods. Neuroimage, 11, 805–821.
Bhatara, V. S., Lovrein, F., Kirkeby, J., Swayze, V., Unruh, E., & Johnson, V. (2002). Brain function in fetal alcohol syndrome assessed by single photon emission computed tomography. South Dakota Journal of Medicine, 55, 59–62.
Bookheimer, S. Y., & Sowell, E. R. (2005). Brain imaging in FAS commentary on the article by Malisza et al. Pediatric Research, 58, 1148–1149.
Bookstein, F. L., Streissguth, A. P., Sampson, P. D., Connor, P. D., & Barr, H. M. (2002). Corpus callosum shape and neuropsychological deficits in adult males with heavy fetal alcohol exposure. Neuroimage, 15, 233–251.
Brown, R. T., Coles, C. D., Smith, I. E., Platzman, K. A., Silverstein, J., Erickson, S., et al. (1991). Effects of prenatal alcohol exposure at school age. II. Attention and behavior. Neurotoxicology and Teratology, 13, 369–376.
Cohen, M. S. (1997). Parametric analysis of fMRI data using linear systems methods. Neuroimage, 6, 93–103.
Coles, C. D. (2001). Fetal alcohol exposure and attention: Moving beyond ADHD. Alcohol Research & Health, 25, 199–203.
Coles, C. D., Platzman, K. A., Lynch, M. E., & Freides, D. (2002). Auditory and visual sustained attention in adolescents prenatally exposed to alcohol. Alcoholism: Clinical and Experimental Research, 26, 263–271.
Coles, C. D., Platzman, K. A., RaskindHood, C. L., Brown, R. T., Falek, A., & Smith, I. E. (1997). A comparison of children affected by prenatal alcohol exposure and attention deficit hyperactivity disorder. Alcoholism: Clinical and Experimental Research, 21, 150–161.
Coles, C. D., Smith, I., Fernhoff, P. M., & Falek, A. (1985). Neonatal neurobehavioral characteristics as correlates of maternal alcohol use during gestation. Alcoholism: Clinical and Experimental Research, 9, 454–460.
Connor, P. D., Sampson, P. D., Bookstein, F. L., Barr, H. M., & Streissguth, A. P. (2000). Direct and indirect effects of prenatal alcohol damage on executive function. Developmental neuropsychology, 18, 331–354.
Connor, P. D., Streissguth, A. P., Sampson, P. D., Bookstein, F. L., & Barr, H. M. (1999). Individual differences in auditory and visual attention among fetal alcohol-affected adults. Alcoholism: Clinical and Experimental Research, 23, 1395–1402.
Corbetta, M., Miezin, F. M., Dobmeyer, S., Shulman, G. L., & Petersen, S. E. (1991). Selective and divided attention during visual discriminations of shape, color, and speed: Functional anatomy by positron emission tomography. Journal of Neuroscience, 11, 2383–2402.
Fujita, I., Tanaka, K., Ito, M., & Cheng, K. (1992). Columns for visual features of objects in monkey inferotemporal cortex. Nature, 360, 343–346.
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001). A voxel-based morphometric study of aging in 465 normal adult human brains. Neuroimage, 14, 21–36.
Guerri, C., & RenauPiqueras, J. (1997). Alcohol, astroglia, and brain development. Molecular Neurobiology, 15, 65–81.
Kanwisher, N., & Wojciulik, E. (2000). Visual attention: Insights from brain imaging. Nature Reviews. Neuroscience, 1, 91–100.
Kastner, S., Weerd, P. D., Desimone, R., & Ungerleider, L. G. (1998). Mechanisms of directed attention in the human extrastriate cortex as revealed by functional MRI. Science, 282, 108–111.
Kopera-Frye, K., Olson, H. C., & Streissguth, A. P. (1997). Teratogenic effects of alcohol on attention. In J. A. J. T. BurackEnns (Ed.) Attention, development and psychopathology (pp. 171–204). New York: Guilford.
Le, T. H., Pardo, J. V., & Hu, X. (1998). 4T-fMRI study of nonspatial shifting of selective attention: Cerebellar and parietal contributions. Journal of Neurophysiology, 79, 1535–1548.
Luck, S. J., Chelazzi, L., Hillyard, S. A., & Desimone, R. (1997). Neural mechanisms of spatial selective attention in areas V1, V2, and V4 of macaque visual cortex. Journal of Neurophysiology, 77, 24–42.
Ma, X., Coles, C. D., Lynch, M. E., LaConte, S. M., Zurkiya, O., Wang, D., et al. (2005). Evaluation of corpus callosum anisotropy in young adults with fetal alcohol syndrome according to diffusion tensor imaging. Alcoholism: Clinical and Experimental Research, 29, 1214–1222.
Malisza, K. L., Allman, A.-A., Shiloff, D., Jakobson, L., Longstaffe, S., & Chudley, A. E. (2005). Evaluation of spatial working memory function in children and adults with fetal alcohol spectrum disorders: A functional magnetic resonance imaging study. Pediatric Research, 58, 1150–1157.
Mattson, S. N., Calarco, K. E., & Lang, A. R. (2006). Focused and shifting attention in children with heavy prenatal alcohol exposure. Neuropsychology, 20, 361–369.
Mattson, S. N., Riley, E. P., Delis, D. C., Stern, C., & Jones, K. L. (1996). Verbal learning and memory in children with fetal alcohol syndrome. Alcoholism: Clinical and Experimental Research, 20, 810–816.
Metz, C. E. (1978). Basic principles of ROC analysis. Seminars in Nuclear Medicine, 8, 283–298.
Mirsky, A. F. (1996). Disorders of attention: a neuropsychological perspective. In G. R. N. A. LyonKrasnegor (Ed.) Attention, memory and executive function (pp. 71–95). Baltimore: Paul H Brookes.
Nanson, J. L., & Hiscock, M. (1990). Attention deficits in children exposed to alcohol prenatally. Alcoholism: Clinical and Experimental Research, 14, 656–661.
Riikonen, R., Salonen, I., Partanen, K., & verho, S. (1999). Brain perfusion SPECT and MRI in foetal alcohol syndrome. Developmental Medicine & Child Neurology, 41, 652–659.
Riley, E. P., Mattson, S. N., Sowell, E. R., Jernigan, T. L., Sobel, D. F., & Jones, K. L. (1995). Abnormalities of the corpus callosum in children prenatally exposed to alcohol. Alcoholism: Clinical and Experimental Research, 19, 1198–1202.
Schonfeld, A. M., Mattson, S. N., Lang, A. R., Delis, D. C., & Riley, E. P. (2001). Verbal and nonverbal fluency in children with heavy prenatal alcohol exposure. Journal of Studies on Alcohol, 62, 239–246.
Sowell, E. R., Mattson, S. N., Thompson, P. M., Jernigan, T. L., Riley, E. P., & Toga, A. W. (2001a). Mapping callosal morphology and cognitive correlates: Effect of heavy prenatal alcohol exposure. Neurology, 57, 235–244.
Sowell, E. R., Thompson, P. M., Mattson, S. N., Tessner, K. D., Jernigan, T. L., Riley, E. P., et al. (2001b). Voxel-based morphometric analysis of the brain in children and adolescents prenatally exposed to alcohol. Neuroreport, 12, 515–523.
Sowell, E. R., Thompson, P. M., Mattson, S. N., Tessner, K. D., Jernigan, T. L., Riley, E. P., et al. (2002). Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposure. Cerebral Cortex, 12, 856–865.
Talairach, J., & Tournoux, P. (1988). Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical Publishers, Inc.
Till, C., Westall, C. A., Koren, G., Nulman, I., & Rovet, J. F. (2005). Vision abnormalities in young children exposed prenatally to organic solvents. Neurotoxicology, 26(4), 599–613.
Wilkinson, F., & Wilson, H. R. (2001). Global processes in from vision and their relationship to spatial attention. In M. L. JenkinHarris (Ed.)Vision and attention (pp. 63–81). New York: Springer.
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This work is supported by NIH grants RO1AA014373, RO1EB002009 and Georgia Research Alliance.
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Li, Z., Coles, C.D., Lynch, M.E. et al. Occipital-temporal Reduction and Sustained Visual Attention Deficit in Prenatal Alcohol Exposed Adults. Brain Imaging and Behavior 2, 39–48 (2008). https://doi.org/10.1007/s11682-007-9013-0
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DOI: https://doi.org/10.1007/s11682-007-9013-0