Nano Express

Nanoscale Research Letters

, Volume 5, Issue 7, pp 1093-1101

Open Access This content is freely available online to anyone, anywhere at any time.

Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy

  • Gianni CiofaniAffiliated withCenter of MicroBioRobotics c/o Scuola Superiore Sant’Anna, Italian Institute of Technology Email author 
  • , Serena DantiAffiliated withCUCCS-RRMR, University of Pisa
  • , Delfo D’AlessandroAffiliated withCUCCS-RRMR, University of PisaDepartment of Human Morphology and Applied Biology, University of Pisa
  • , Stefania MoscatoAffiliated withDepartment of Human Morphology and Applied Biology, University of Pisa
  • , Mario PetriniAffiliated withCUCCS-RRMR, University of PisaDepartment of Oncology and Transplants, University of Pisa
  • , Arianna MenciassiAffiliated withCenter of MicroBioRobotics c/o Scuola Superiore Sant’Anna, Italian Institute of TechnologyScuola Superiore Sant’Anna

Abstract

In the latest years, innovative nanomaterials have attracted a dramatic and exponentially increasing interest, in particular for their potential applications in the biomedical field. In this paper, we reported our findings on the cytocompatibility of barium titanate nanoparticles (BTNPs), an extremely interesting ceramic material. A rational and systematic study of BTNP cytocompatibility was performed, using a dispersion method based on a non-covalent binding to glycol-chitosan, which demonstrated the optimal cytocompatibility of this nanomaterial even at high concentration (100 μg/ml). Moreover, we showed that the efficiency of doxorubicin, a widely used chemotherapy drug, is highly enhanced following the complexation with BTNPs. Our results suggest that innovative ceramic nanomaterials such as BTNPs can be realistically exploited as alternative cellular nanovectors.

Keywords

Barium titanate nanoparticles Glycol-chitosan Doxorubicin Neuroblastoma Cancer therapy