Nano Express

Nanoscale Research Letters

, Volume 5, Issue 4, pp 781-785

Open Access This content is freely available online to anyone, anywhere at any time.

Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug

  • Shao-Wen CaoAffiliated withState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of SciencesGraduate School of Chinese Academy of Sciences
  • , Ying-Jie ZhuAffiliated withState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of SciencesGraduate School of Chinese Academy of Sciences Email author 
  • , Jin WuAffiliated withState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of SciencesGraduate School of Chinese Academy of Sciences
  • , Ke-Wei WangAffiliated withState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of SciencesGraduate School of Chinese Academy of Sciences
  • , Qi-Li TangAffiliated withState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of SciencesGraduate School of Chinese Academy of Sciences

Abstract

The P123/ACP nanocomposite with sizes less than 100 nm consisting of triblock copolymer P123 and amorphous calcium phosphate (ACP) has been prepared by using an aqueous solution containing CaCl2, (NH4)3PO4, and P123 at room temperature. The P123/ACP nanocomposite is used as the nanocarrier for hydrophobic drug ibuprofen, based on the combined advantages of both amphiphilic block copolymer and calcium phosphate delivery system. The P123/ACP nanocomposite has a much higher ibuprofen loading capacity (148 mg/g) than the single-phase calcium phosphate nanostructures. The drug release percentage of the P123/ACP nanocomposite in simulated body fluid reaches about 100% in a period of 156 h, which is much slower than that of single-phase calcium phosphate nanostructures. It is expected that the P123/ACP nanocomposite is promising for the application in the controlled delivery of hydrophobic drugs.

Keywords

Nanocomposite P123 Calcium phosphate Hydrophobic drug Sustained release