Nano Express

Nanoscale Research Letters

, 5:753

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy

  • Aliaksandra RakovichAffiliated withSchool of Physics and CRANN Research Centre, Trinity College
  • , Diana SavateevaAffiliated withBrest State Technical University
  • , Tatsiana RakovichAffiliated withSchool of Biochemistry and Immunology, Trinity College
  • , John F. DoneganAffiliated withSchool of Physics and CRANN Research Centre, Trinity College
  • , Yury P. RakovichAffiliated withSchool of Physics and CRANN Research Centre, Trinity College Email author 
  • , Vincent KellyAffiliated withSchool of Biochemistry and Immunology, Trinity College
  • , Vladimir LesnyakAffiliated withPhysikalische Chemie/Elektrochemie, TU Dresden
  • , Alexander EychmüllerAffiliated withPhysikalische Chemie/Elektrochemie, TU Dresden

Abstract

We have studied the photodynamic properties of novel CdTe quantum dots—methylene blue hybrid photosensitizer. Absorption spectroscopy, photoluminescence spectroscopy, and fluorescence lifetime imaging of this system reveal efficient charge transfer between nanocrystals and the methylene blue dye. Near-infrared photoluminescence measurements provide evidence for an increased efficiency of singlet oxygen production by the methylene blue dye. In vitro studies on the growth of HepG2 and HeLa cancerous cells were also performed, they point toward an improvement in the cell kill efficiency for the methylene blue-semiconductor nanocrystals hybrid system.

Keywords

Quantum dots Nanocrystals Photosensitiser Electron transfer Singlet oxygen