Nano Express

Nanoscale Research Letters

, Volume 5, Issue 3, pp 631-636

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances

  • K. V. PurtovAffiliated withInstitute of Biophysics SB RAS Email author 
  • , A. I. PetuninAffiliated withMedical Research Company «Dias»
  • , A. E. BurovAffiliated withInstitute of Computational Modeling SB RAS
  • , A. P. PuzyrAffiliated withInstitute of Biophysics SB RAS
  • , V. S. BondarAffiliated withInstitute of Biophysics SB RAS


Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgGI125 and RAM-nanodiamond-BSAI125 complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSAI125 complex is able to bind to the target antigen immobilized on the Sepharose 6B matrix through antibody–antigen interaction. The idea can be extended to use nanodiamonds as carriers for delivery of bioactive substances (i.e., drugs) to various targets in vivo.


Nanodiamonds Ligand Protein immobilization Nanocarrier Targeted delivery