Nano Express

Nanoscale Research Letters

, Volume 4, Issue 12, pp 1395-1402

Open Access This content is freely available online to anyone, anywhere at any time.

Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation

  • Dadong GuoAffiliated withState Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University
  • , Chunhui WuAffiliated withState Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University
  • , Jingyuan LiAffiliated withState Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University
  • , Airong GuoAffiliated withState Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University
  • , Qingning LiAffiliated withState Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University
  • , Hui JiangAffiliated withState Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University
  • , Baoan ChenAffiliated withZhongda Hospital, School of Clinical Medical, Southeast University
  • , Xuemei WangAffiliated withState Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University Email author 

Abstract

The effect of functionalized nickel (Ni) nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells (SMMC-7721) has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Meanwhile, the influence of Ni nanoparticles and/or quercetin on cell proliferation has been further evaluated by the real-time cell electronic sensing (RT-CES) study. Our observations indicate that Ni nanoparticles could efficiently improve the permeability of cancer cell membrane, and remarkably enhance the accumulation of quercetin in SMMC-7721 cells, suggesting that Ni nanoparticles and quercetin would facilitate the synergistic effect on inhibiting proliferation of cancer cells.

Keywords

Nickel nanoparticles Real-time cell electronic sensing (RT-CES) study MTT assay Electrochemical analysis Hepatocellular carcinoma cell line