Nano Express

Nanoscale Research Letters

, 4:854

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields

  • Uwe M ReinscheidAffiliated withMax-Planck-Institute for Biophysical Chemistry Email author 


The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution.


Gold nanoparticle Magnetic field Relaxation Hydrolysis Pro-drug