Nano Express

Nanoscale Research Letters

, Volume 4, Issue 6, pp 544-549

Open Access This content is freely available online to anyone, anywhere at any time.

Nanostructured Biomaterials with Controlled Properties Synthesis and Characterization

  • Eugenia TeodorAffiliated withNational Institute for Biological Sciences-Centre of Bioanalysis Email author 
  • , Simona Carmen LiţescuAffiliated withNational Institute for Biological Sciences-Centre of Bioanalysis
  • , C. PetcuAffiliated withNational Institute for Chemistry & Petrochemistry
  • , Mihaela MihalacheAffiliated withNational Institute for Biological Sciences-Centre of Bioanalysis
  • , Raluca SomoghiAffiliated withNational Institute for Chemistry & Petrochemistry

Abstract

Magnetic nanoparticles were obtained using an adjusted Massart method and were covered in a layer-by-layer technique with hydrogel-type biocompatible shells, from chitosan and hyaluronic acid. The synthesized nanocomposites were characterized using dynamic light scattering, transmission electron microscopy, and Fourier transformed infrared spectroscopy. Biocompatibility of magnetic nanostructures was determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) cell proliferation assay, swelling tests, and degradation tests. In addition, interaction of hydrogel-magnetic nanoparticles with microorganisms was studied. The possibility of precise nanoparticles size control, as long as the availability of bio-compatible covering, makes them suitable for biomedical applications.

Keywords

Magnetic nanoparticles Hydrogels Layer-by-layer technique Biocompatibility