Abstract
Objective
To get better recognition of central neurocytoma and diminish misdiagnosis.
Methods
A retrospective review identified 15 cases of central neurocytoma. All cases of central neurocytoma were analyzed for their clinical symptoms, pathologic changes, immunohistochemical staining, prognosis and differential diagnosis. Clinical follow up was performed.
Results
There were 8 males and 7 females aged 10–64 years (median 32.93 years). The most common presenting symptoms were those related to increased intracranial pressure (ICP), including headache (100%), papilledema (93%) and vomiting (80%). All tumors were located in the ventricular system. The tumors were composed of uniform cells with round nuclei and a fine chromatin pattern, and in some areas, small cells with perinuclear halo could be seen. In particular, the anuclear areas may have a fine fibrillary matrix (neuropil). Nuclear atypia and vascular proliferation appeared in two cases, respectively. Focal necrosis could be seen in one case. Immunohistochemical findings included expression of synaptophysin (15/15), neuron specific enolase (12/15) and glial fibrillary acidic protein (GFAP) (3/15). MIB-1 proliferation index ranged from 0.8–12.5%, and was more than 2% in 3 of 15 cases assessed. Follow-up information of 11 patients was available.
Conclusions
Central neurocytoma has a favorable prognosis in general, but in some cases, the clinical course could be aggressive. Increase of GFAP positivity, proliferation index and vascular proliferation might suggest a more malignant process.
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References
Choudhari KA, Kaliaperumal C, Jain A, et al. Central neurocytoma: a multi-disciplinary review. Br J Neurosurg 2009;23:585–595.
Hassoun J, Gambarelli D, Grisoli F, et al. Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol 1982;56:151–156.
Mrak RE. Malignant neurocytic tumor. Hum Pathol 1994;25:747–752.
Söylemezoglu F, Scheithauer BW, Esteve J, et al. Atypical central neurocytoma. J Neuropathol Exp Neurol 1997;56:551–556.
Sharma MC, Deb P, Sharma S, et al. Neurocytoma: a comprehensive review. Neurosurg Rev 2006;29:270–285; discussion 285.
Brat DJ, Scheithauer BW, Eberhart CG, et al. Extraventricular neurocytomas: pathologic features and clinical outcome. Am J Surg Pathol 2001;25:1252–1260.
Vasiljevic A, François P, Loundou A, et al. Prognostic factors in central neurocytomas: a multicenter study of 71 cases. Am J Surg Pathol 2012;36:220–227.
Chen CM, Chen KH, Jung SM, et al. Central neurocytoma: 9 case series and review. Surg Neurol 2008;70:204–209.
Chen CL, Shen CC, Wang J, et al. Central neurocytoma: a clinical, radiological and pathological study of nine cases. Clin Neurol Neurosurg 2008;110:129–136.
Rodriguez FJ, Mota RA, Scheithauer BW, et al. Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma. Brain Pathol 2009;19:623–629.
Fujisawa H, Marukawa K, Hasegawa M, et al. Genetic differences between neurocytoma and dysembryoplastic neuroepithelial tumor and oligodendroglial tumors. J Neurosurg 2002;97:1350–1355.
Figarella-Branger D, Pellissier JF, Daumas-Duport C, et al. Central neurocytomas. Critical evaluation of a smallcell neuronal tumor. Am J Surg Pathol 1992;16:97–109.
Vallat-Decouvelaere AV, Gauchez P, Varlet P, et al. Socalled malignant and extra-ventricular neurocytomas: reality or wrong diagnosis? A critical review about two overdiagnosed cases. J Neurooncol 2000;48:161–172.
Westphal M, Stavrou D, Nausch H, et al. Human neurocytoma cells in culture show characteristics of astroglial differentiation. J Neurosci Res 1994;38:698–704.
Ishiuchi S, Nakazato Y, Iino M, et al. In vitro neuronal and glial production and differentiation of human central neurocytoma cells. J Neurosci Res 1998;51:526–535.
Sharma MC, Rathore A, Karak AK, et al. A study of proliferative markers in central neurocytoma. Pathology 1998;30:355–359.
Yano H, Ohe N, Shinoda J, et al. Immunohistochemical study concerning the origin of neurocytoma—a case report. Pathol Oncol Res 2009;15:301–305.
Feiden S, Feiden W. WHO classification of tumours of the CNS: revised edition of 2007 with critical comments on the typing und grading of common-type diffuse gliomas. Pathologe 2008;29:411–421.
Chen CM, Chen KH, Jung SM, et al. Central neurocytoma: 9 case series and review. Surg Neurol 2008;70:204–209.
Bazarbacha HM, Zouaoui W, Sebai R, et al. Central neurocytoma. Tunis Med 2006;84:572–577.
Rajesh LS, Jain D, Radotra BD, et al. Central neurocytoma: a clinico-pathological study of eight cases. Indian J Pathol Microbiol 2006;49:543–545.
De Tommasi A, D’Urso PI, De Tommasi C, et al. Central neurocytoma: two case reports and review of the literature. Neurosurg Rev 2006;29:339–347.
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Li, Y., Ye, XF., Qian, G. et al. Pathologic features and clinical outcome of central neurocytoma: analysis of 15 cases. Chin. J. Cancer Res. 24, 284–290 (2012). https://doi.org/10.1007/s11670-012-0265-x
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DOI: https://doi.org/10.1007/s11670-012-0265-x