Review

Chinese Journal of Cancer Research

, Volume 22, Issue 2, pp 87-92

Antioxidant enzymes and cancer

  • Md. Asaduzzaman KhanAffiliated withDepartment of Biochemistry, School of Biological Science and Technology, Central South University
  • , Mousumi TaniaAffiliated withDepartment of Biochemistry, School of Biological Science and Technology, Central South University
  • , Dian-zheng ZhangAffiliated withDepartment of Biochemistry, School of Biological Science and Technology, Central South UniversityDepartment of Biochemistry/Molecular Biology and Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine
  • , Han-chun ChenAffiliated withDepartment of Biochemistry, School of Biological Science and Technology, Central South University Email author 

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Abstract

Although oxidation is the most common biological and energy producing reaction, oxidative stress is harmful to cell, because the products of oxidation such as free radicals and peroxides damage the cellular components, causing several diseases. Damage in DNA is responsible for cancer formation and progression. However, several enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase etc. act as antioxidants to influence oxidative stress. Polymorphisms in these enzymes are supposed to be associated with DNA damage and subsequently the individual’s risk of cancer susceptibility. This review article aims to further elucidate the relationship between antioxidant enzymes and cancers by summarizing the findings of some of the important study concerning expression levels and genetic polymorphisms of antioxidant enzymes in cancer patients.

Keywords

Superoxide dismutase Catalase Glutathione peroxidase Glutathione-S-Transferase Cancer

CLCnumber

R730.231