Symposium: Bulk Metallic Glasses VI

Metallurgical and Materials Transactions A

, Volume 41, Issue 7, pp 1726-1734

Biocompatibility Study of Zirconium-Based Bulk Metallic Glasses for Orthopedic Applications

  • Wei HeAffiliated withDepartment of Materials Science and Engineering, University of TennesseeDepartment of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee Email author 
  • , Andrew ChuangAffiliated withDepartment of Materials Science and Engineering, University of Tennessee
  • , Zheng CaoAffiliated withDepartment of Materials Science and Engineering, University of Tennessee
  • , Peter K. LiawAffiliated withDepartment of Materials Science and Engineering, University of Tennessee

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Abstract

Bulk metallic glasses (BMGs) represent an emerging class of materials that offer an attractive combination of properties, such as high strength, low modulus, good fatigue limit, and near-net-shape formability. The BMGs have been explored in mechanical, chemical, and magnetic applications. However, little research has been attracted in the biomedical field. In this work, we study the potential of BMGs for the orthopedic repair and replacement. We report the biocompatibility study of zirconium (Zr)–based solid BMGs using mouse osteoblast cells. Cell attachment, proliferation, and differentiation are compared to Ti-6Al-4V, a well-studied alloy biomaterial. Our in-vitro study has demonstrated that cells cultured on the Zr-based BMG substrate showed higher attachment, alkaline phosphatase activity, and bone matrix deposition compared to those grown on the control Ti alloy substrate. Cytotoxicity staining also revealed the remarkable viability of cells growing on the BMG substrates.