Abstract
Objective
To investigate the relationship between inflammatory factors and two Chinese medicine (CM) syndrome types of qi stagnation and blood stasis (QSBS) and qi deficiency and blood stasis (QDBS) in patients with acute coronary syndrome (ACS).
Methods
Sixty subjects with ACS, whose pathogenesis changes belongs to qi disturbance blood stasis syndrome, were divided into 2 groups: 30 in the QSBS group and 30 in the QDBS group. The comparative analysis on them was carried out through comparing general information, coronary angiography and inflammatory factors including intracellular adhesion molecule-1 (ICAM-1), chitinase-3-like protein 1 (YKL-40) and lipoprotein-associated phospholipase A2 (Lp-PLA2).
Results
Compared with the QSBS group, Lp-PLA2 and YKL-40 levels in the QDBS group showed no-significant difference (P>0.05); ICAM-1 was significantly higher in the QDBS group than in the QSBS group in the pathological processes of qi disturbance and blood stasis syndrome of ACS (P<0.05).
Conclusions
Inflammatory factor ICAM-1 may be an objective basis for syndrome typing of QSBS and QDBS, which provides a research direction for standardization research of CM syndrome types.
Similar content being viewed by others
References
Braunwald E, Califf RM, Cannon CP, Fox KA, Fuster V, Gibler WB, et al. Redefining medical treatment in the management of unstable angina. Am J Med 2000;108:41–53.
Ma CY, Liu JH, Ma Q, Wang SP, Ren FX, et al. A study of relationship between coronary heart disease and markers of vessel endothelial cells. Chin J Intervent Cardiol (Chin) 2016;2:104–106.
Ghimire G, Gupta A, Hage FG. Guidelines in review: 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction. J Nucl Cardiol 2014;21:190–191.
Chinese Society of Cardiology of Chinese Medical Association, Editorial Board of Chinese Journal of Cardiology. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Chin J Cardiol (Chin) 2012;40:353–367.
Cardio vascular Center, China Society of Integrated Traditional Chinese. Chinese medicine syndrome differentiation standards of coronary heart disease. Chin J Integr Tradit West Med (Chin) 1991;5:257–257.
Fu CG, Gao ZY, Wang PL, Wang CL, Xu H, Shi DZ, et al. Study on the diagnostic criteria for coronary heart disease patients of blood stasis syndrome. J Chin Integr Med (Chin) 2012;32:1285–1286.
Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51:606.
Eid RE, Rao DA, Zhou J, Lo SF, Ranibaran H, Gallo A, et al. Interleukin-7 and interferongamma are produced concomitantly by human coronary arteryinfiltrating T cells and act synergistically on vascular smooth muscle. Circulation 2009;119:1424–1432.
Wilson PW, Peter AHA. WFCDC/AHA workshop on markers of inflammation and cardiovascular disease: application to clinical and public health practice: ability of inflammatory markers to predict disease in asymptomatic patients: a background paper. Circulation 2004;110:568.
Chou CH, Ueng KC, Liu YF, Wu CH, Yang SF, Wang PH. Impact of intercellular adhesion molecule-1 genetic polymorphisms on coronary artery disease susceptibility in Taiwanese subjects. Int J Med Sci 2015;12: 510–516.
Zheng JL, Lu L, Hu J, Zhang RY, Zhang Q, Chen QJ. Increased serum YKL-40 and C—reactive protein levels are associated with angiographie lesion progression in patients with coronary artery disease. Atherosclerois 2010;210:590–595.
Zheng GH, Xiong SQ, Mei LJ, Chen HY, Wang T, Chu JF. Elevated plasma platelet activating factor, platelet activating factor acetylhydrolase levels and risk of coronary heart disease or blood stasis syndrome of coronary heart disease in Chinese: a case control study: a case-control study. Inflammation 2012;35:1419–28.
Gu X, Hou J, Yang S, Yu H, Tian J, Liu F, et al. Is lipoprotein-associated phospholipase A2 activity correlated with fibrous-cap thickness and plaque volume in patients with acute coronary syndrome? Coron Artery Dis 2014;25:10–15.
Tang QD, Wu PS, Li YH, Hou YQ, Xie JJ, Yu TH, et al. Clinical value of plasma level of Lp-LPA2 in patients with acute coronary syndrome Chin J Arterioscler (Chin) 2012;20:829–832.
Maiolino G, Lenzini L, Pedon L, Cesari M, Seccia TM, Frigo AC, et al. Lipoprotein-associated phospholipase A2 activity predicts cardiovascular events in high risk coronary artery disease patients. J Cardiovasc Med 2015;16:29–36.
Ren JX, Liu JX, Lin CR, Miao YA. Comparative analysis on the biological basis of blood stasis syndrome and by qi stagnation and qi deficiency inpatients with unstable angina pectoris. J Chin Integr Med (Chin) 2010;30:352–356.
Hong YD, Huang YS, Wu H, Cheng YP, Li FY, Mo HH. Clinical studies on relationship between TCM syndromes of coronary heart disease and inflammatory factors. J Guangzhou Univ Tradit Chin Med (Chin) 2005;22:81–86.
Yi ZG, Wang Q, Zhang SQ. Correlation study between TCM syndromes of acute coronary syndrome and IL-18, Hs-CRP. Jiangsu J Tradit Chin Med (Chin) 2007;39:22–23.
Chu FY, Wang J, Yao KW, Li ZZ. Correlation study betwwen TCM syndrome differentiation and blood lipid and coronary angiography in patients with coronary heart disease. Beijing J Tradit Chin Med (Chin) 2009;28:918–921.
Author information
Authors and Affiliations
Corresponding authors
Additional information
Supported by National Basic Research Program of China (973 program, No. 2015CB554404)
Rights and permissions
About this article
Cite this article
Ma, Cy., Liu, Jh., Liu, Jx. et al. Relationship between two blood stasis syndromes and inflammatory factors in patients with acute coronary syndrome. Chin. J. Integr. Med. 23, 845–849 (2017). https://doi.org/10.1007/s11655-016-2746-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11655-016-2746-0