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Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial

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Abstract

Objectives

To investigate whether three strains of probiotics, L. acidophilus, L. rhamnosus, and L. sporogenes, had signifificant inhibitive effects on Helicobacter pylori (H. pylori).

Methods

This is a 4-week, randomly assigned, parallel-group, doubled-blind, and placebo-controlled study. Fifty patients with a positive H. pylori infection urea breath test (△UBT) result > 10% and without ulcer symptoms were randomized into a treatment group and a placebo group by a computer generated allocation sheet with 1:1. These subjects took one capsule of probiotics or placebo twice daily. The primary measurement was the change in △UBT values.

Results

The △UBT values during the 4-week treatment period and the 2-week follow-up period were not signifificantly different between the treatment group and the placebo group, indicating that the inhibitive effects on H. pylori were comparable between both groups. The monocyte count (%) was 5.77±1.11 in the treatment group versus 5.09±1.12 in the placebo group (P=0.044), and the basophile count was 0.55±0.32 in the treatment group versus 0.36±0.23 in the placebo group (P=0.024) at week 2 of the treatment period, both of which reached statistical signifificance. The monocyte count was 5.75±1.26 in the treatment group and 4.72±0.99 in the placebo group at the end of the follow-up period (P=0.003).

Conclusion

There was no signifificant inhibitive effects of the three probiotic strains (L. acidophilus, L. rhamnosus, and L. sporogenes) on H. pylori. Probiotics can not play the same role as antibiotics in the eradication of H. pylori, the role of probiotics is likely to be important as adjuvant to the triple or quadruple therapy for H. pylori, especially in resistance cases.

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Author information

Authors and Affiliations

  1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 40201, China

    Chien-Ying Lee & Chun-Che Lin

  2. Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan, 40201, China

    Chien-Ying Lee, Ya-Lan Chang, Yi-Ching Lee & Yu-Hsiang Kuan

  3. Department of Medicine, Chung Shan Medical University, Taichung, Taiwan, China

    Chien-Ying Lee, Hung-Che Shih, Ya-Lan Chang, Yi-Ching Lee, Yu-Hsiang Kuan & Chun-Che Lin

  4. Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan, 40201, China

    Min-Chien Yu

  5. Department of Statistics and Informatics Science, Providence University, China, 43301, China

    Ming-Yung Lee

  6. Department of Applied Cosmetology, National Tainan Junior College of Nursing, Taiwan, 700, China

    Ya-Yun Lai

  7. Division of Hepatogastroenterology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan, 40201, China

    Chun-Che Lin

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  1. Chien-Ying Lee
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Correspondence to Chun-Che Lin.

Additional information

Supported by the Ministry of Economic Affairs (Contract No. 9931201029-7-1), Taiwan, China and Chung Shan Medical University (Protocol No.: CSMU-G1040001)

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Lee, CY., Shih, HC., Yu, MC. et al. Evaluation of the potential inhibitory activity of a combination of L. acidophilus, L. rhamnosus and L. sporogenes on Helicobacter pylori: A randomized double-blind placebo-controlled clinical trial. Chin. J. Integr. Med. 23, 176–182 (2017). https://doi.org/10.1007/s11655-016-2531-0

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  • DOI: https://doi.org/10.1007/s11655-016-2531-0

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