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The Aqueous Fraction of Areca catechu Nut Ameliorates Demyelination in Prefrontal Cortex-Induced Depressive Symptoms and Cognitive Decline through Brain-Derived Neurotrophic Factor-Cyclic Adenosine Monophosphate Response Element-Binding Activation

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Abstract

Objective

To investigate if Areca catechu L. treatment could ameliorate depressive symptoms and cognitive decline by facilitating myelination processes in prefrontal cortex.

Methods

A mouse model of cuprizoneinduced demyelination was used to mimic demyelinating disease. Two concentrations of A. catechu nut extract (ANE; 1% and 2%) were administered orally in the diet for 8 weeks. Depressive symptoms and cognition-associated behaviors were evaluated in tests of locomotor activity, tail suspension, and forced swimming; spatial memory was tested with the Y-maze. Expression of myelin basic protein (MBP), 2′,3′-cyclic-nucleotide 3′-phosphodiesterase (CNPase), glutathione S-transferases pi (GSTpi), brain-derived neurotrophic factor (BDNF), and the transcription factor cyclic adenosine monophosphate (cAMP) response element-binding (CREB) were evaluated by western blot.

Results

Animals subjected to demyelination showed hyperactivity (P<0.01), impaired spatial memory (P<0.01), and depressive behaviors (P<0.05). Internally, they displayed signifificant myelin damage in the cortex, lower expression of CNPase and GSTpi, slightly decreased BDNF (P>0.05), and signifificantly reduced p-CREB (P<0.05). Nevertheless, ANE treatment demonstrated signifificant anti-depressant activity and enhancement of working memory (P<0.05 or 0.01). In addition, ANE treatment increased MBP, CNPase and GSTpi protein expression in prefrontal cortex (P<0.05). Concomitant with increased BDNF production (P<0.05), ANE treatment up-regulated phosphorylated CREB, but without statistical signifificance (P>0.05).

Conclusion

ANE treatment might ameliorate depressive symptoms and cognitive decline by facilitating myelination processes in prefrontal cortex via induction of BDNF-CREB activation.

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Authors and Affiliations

  1. Mental Health Research Laboratory, Xiamen Xianyue Hospital, Xiamen, Fujian Province, 361012, China

    Abulimiti Adilijiang  (阿地里江•阿布力米提), Zhi-zhong Xu  (徐志忠) & Wen-qiang Wang  (王文强)

  2. Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, 1E7.31 Walter C. Mackenzie Health Sciences Centre, Edmonton, AB, T6G 2B7, Canada

    Abulimiti Adilijiang  (阿地里江•阿布力米提), Kelly Hartle, Yan-bo Zhang  (张彦波) & Xin-min Li  (李新民)

  3. Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, Winnipeg, MB, R3E 0J9, Canada

    Teng Guan  (关腾)

Authors
  1. Abulimiti Adilijiang  (阿地里江•阿布力米提)
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  2. Teng Guan  (关腾)
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  3. Zhi-zhong Xu  (徐志忠)
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  4. Kelly Hartle
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  5. Yan-bo Zhang  (张彦波)
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  6. Wen-qiang Wang  (王文强)
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  7. Xin-min Li  (李新民)
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Corresponding author

Correspondence to Wen-qiang Wang  (王文强).

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Supported by the Canadian Institutes of Health Research Funding

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Adilijiang, A., Guan, T., Xu, Zz. et al. The Aqueous Fraction of Areca catechu Nut Ameliorates Demyelination in Prefrontal Cortex-Induced Depressive Symptoms and Cognitive Decline through Brain-Derived Neurotrophic Factor-Cyclic Adenosine Monophosphate Response Element-Binding Activation. Chin. J. Integr. Med. (2016). https://doi.org/10.1007/s11655-016-2455-8

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  • DOI: https://doi.org/10.1007/s11655-016-2455-8

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