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Effects of Modified Qing’e Pill (加味青娥丸) on expression of adiponectin, bone morphogenetic protein 2 and coagulation-related factors in patients with nontraumatic osteonecrosis of femoral head

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Abstract

Objectives

To observe the regulation of Chinese herbal medicine, Modifified Qing’e Pill (加味青娥丸, MQEP), on the expression of adiponectin, bone morphogenetic protein 2 (BMP2), osteoprotegerin (OPG) and other potentially relevant risk factors in patients with nontraumatic osteonecrosis of the femoral head (ONFH).

Methods

A total of 96 patients with nontraumatic ONFH were unequal randomly divided into treatment group (60 cases) and control group (36 cases). The treatment group were treated with MQEP while the control group were treated with simulated pills. Both groups were given caltrate D. Six months were taken as a treatment course. Patients were followed up every 2 months. The levels of plasma adiponectin, BMP2, OPG, von Willebrand factor (vWF), von Willebrand factor cleaving protease (vWF-cp), plasminogen activator inhibitor 1 (PAI-1), tissue plasminogen activator (tPA), C-reactive protein (CRP), blood rheology, bone mineral density (BMD) of the femoral head and Harris Hip Score were measured before and after treatment.

Results

After 6 months of treatment, compared with the control group, patients in the treatment group had signifificantly higher adiponectin and BMP2 levels (P<0.01 and P=0.013, respectively), lower vWF, PAI-1 and CRP levels (P=0.019, P<0.01 and P<0.01, respectively), and lower blood rheology parameters. BMD of the femoral neck, triangle area and Harris Hip Score in the treatment group were signifificantly higher than those in the control group. Moreover, plasma adiponectin showed a positive association with BMP2 (r=0.231, P=0.003) and a negative association with PAI-1 (r=–0.159, P<0.05).

Conclusion

MQEP may play a protective role against nontraumatic ONFH by increasing the expression of adiponectin, regulating bone metabolism and improving the hypercoagulation state, which may provide an experimental base for its clinical effects.

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Authors and Affiliations

  1. Department of Integrated Traditional Chinese Medicine and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Cheng-gang Li, Lin Shen, Yan-Ping Yang, Xiao-Juan Xu, Bo Shuai & Chen Ma

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  1. Cheng-gang Li
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  2. Lin Shen
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  3. Yan-Ping Yang
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  4. Xiao-Juan Xu
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  5. Bo Shuai
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Correspondence to Lin Shen.

Additional information

Supported by the National Natural Science Foundation of China (No. 81273907)

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Li, Cg., Shen, L., Yang, YP. et al. Effects of Modified Qing’e Pill (加味青娥丸) on expression of adiponectin, bone morphogenetic protein 2 and coagulation-related factors in patients with nontraumatic osteonecrosis of femoral head. Chin. J. Integr. Med. 23, 183–189 (2017). https://doi.org/10.1007/s11655-016-2407-3

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  • DOI: https://doi.org/10.1007/s11655-016-2407-3

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